EPISODE · Dec 25, 2025 · 16 MIN
338-TCR 信号经 NFATc1 抑制 IL-15 旁观者激活
from 聊聊Sci
该文章探讨了记忆CD8+ T细胞的激活机制。研究发现，虽然白细胞介素-15（IL-15）能够诱导T细胞受体（TCR）非依赖的旁观者激活，从而表现出自然杀伤细胞（NK）样细胞毒性（例如NKG2D表达升高），但同时发生的TCR信号会抑制这些特征。通过分子机制研究，作者发现TCR激活的Ca²⁺-钙调神经磷酸酶-NFATc1通路通过与AP-1转录因子结合来拮抗IL-15诱导的激活，从而限制了旁观者CD8+ T细胞的NK样功能。此外，文章还定义了一个IL-15特异性基因集，该基因集在急性甲型肝炎患者的旁观者T细胞中得到验证，有助于区分这两种激活模式。References: Lee H, Kim S Y, Kim S H, et al. TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells[J]. Immunity, 2025.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
338-TCR 信号经 NFATc1 抑制 IL-15 旁观者激活
0:00
16:58
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 16 minutes long.
When was this 聊聊Sci episode published?
This episode was published on December 25, 2025.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!