EPISODE · Dec 26, 2025 · 20 MIN
340-轮状病毒感染中 hepcidin-铁失调与新生儿肝损伤
from 聊聊Sci
这篇文章揭示了新生儿轮状病毒（RV）感染导致胆道闭锁（BA）等疾病的潜在病理机制。作者团队通过对BA婴儿和感染RV的小鼠模型进行深入分析，发现持续的I型干扰素（IFN-I）信号传导上调了肝细胞和TREM2+巨噬细胞中的铁调素（hepcidin）表达，进而引发系统性铁超载和脂质过氧化。这项研究证明了铁调素-铁轴在新生儿RV感染和组织损伤中的关键作用，并指出使用叶酸补充剂可以抑制IFN-I-铁调素-铁信号传导，改善铁代谢，从而减轻肝损伤并提高患儿的生存率。References: Xu Y, Chen X, Fang R, et al. A dysregulated hepcidin-iron axis impairs antiviral immunity and induces lethal liver pathology in neonates[J]. Immunity, 2025.前往小宇宙评论区与主播互动
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340-轮状病毒感染中 hepcidin-铁失调与新生儿肝损伤
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