345-组胺信号选择性调控脂肪偏好

这篇文章揭示了调节高脂肪饮食（HFD）偏好的神经基础，区别于高糖饮食（HSD）的摄入机制。研究人员发现，在丘脑室旁核（PVT）内，存在两个不同的神经元亚群，分别介导对高脂肪和高糖食物的摄入。他们进一步确定组胺H3受体（H3Rs）是PVT内高脂肪饮食响应神经元的关键分子标记，并证实H3Rs通过G12/13信号通路特异性地调节脂肪消耗。研究结果表明，这一组胺能通路（TMN HA → PVT HFD）通过对食物口感线索的响应来控制脂肪摄入，为精准体重管理提供了潜在的治疗靶点。References: Zheng Y, Liao J, Fang Z, et al. Biased histamine signaling selectively gates fat preference[J]. Neuron, 2025.前往小宇宙评论区与主播互动

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345-组胺信号选择性调控脂肪偏好

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