EPISODE · Jan 2, 2026 · 16 MIN
353-IL-36γ CAR T重塑中性粒细胞诱导抗肿瘤免疫
from 聊聊Sci
这项研究揭示了装甲型 IL-36γ CAR T 细胞在治疗实体瘤方面的重大突破，该疗法能够克服抗原异质性和免疫抑制环境等传统障碍。这种改良的 T 细胞不仅能直接攻击肿瘤，还能重塑肿瘤微环境，将中性粒细胞转化为具有杀伤力且能提呈抗原的免疫辅助者。通过这种机制，患者自身的免疫系统被重新激活，诱导产生能识别多种肿瘤抗原的内源性 T 细胞响应。这种“抗癌免疫循环”的建立使得该疗法在无需清淋预处理的情况下，即可在多种小鼠模型中实现实体瘤的完全清除。实验证明，治疗后的机体产生了持久的免疫记忆，能够有效抵抗不表达初始靶抗原的肿瘤复发。该发现为提升过继性细胞疗法在治疗复杂实体瘤中的临床疗效提供了全新的策略方向。References: Zuo Y, Vohwinkel D J, Dong B, et al. IL-36γ armored CAR T cells reprogram neutrophils to induce endogenous antitumor immunity[J]. Cancer Cell, 2025.前往小宇宙评论区与主播互动
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353-IL-36γ CAR T重塑中性粒细胞诱导抗肿瘤免疫
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