EPISODE · Jan 4, 2026 · 17 MIN
357-SOX2干细胞调控中性粒细胞抵抗免疫治疗
from 聊聊Sci
这项研究通过单细胞测序和空间转录组技术，揭示了肿瘤起始干细胞（tSCs）如何通过调控中性粒细胞的塑性来抵御免疫治疗。研究发现，虽然免疫治疗能诱导基质中的中性粒细胞转化为抗肿瘤状态，但位于肿瘤-基质界面的 SOX2高表达干细胞却能阻止这种转变。这些干细胞通过直接激活 FADS1 基因产生花生四烯酸（AA），进而触发 PGE2 信号通路以抑制中性粒细胞的干扰素响应。这种机制使中性粒细胞维持在免疫抑制状态，为肿瘤干细胞构建了一个保护性微环境，导致治疗后的癌症复发。该发现为通过阻断 COX-2 等通路来破坏这种细胞间通讯、增强免疫疗效提供了新思路。References: Guo W, Luan J, Huang X, et al. Tumor-initiating stem cells fine-tune the plasticity of neutrophils to sculpt a protective niche[J]. Cancer cell, 2025.前往小宇宙评论区与主播互动
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357-SOX2干细胞调控中性粒细胞抵抗免疫治疗
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