EPISODE · Jan 7, 2026 · 18 MIN
363-PASTA：基于通路导向的空间转录组基因表达填补方法
from 聊聊Sci
本文介绍了一种名为 PASTA 的创新计算框架，旨在提高空间转录组学数据中生物通路基因表达预测的准确性。该方法通过整合单细胞测序（scRNA-seq）参考数据，并结合细胞类型与空间邻域信息，克服了现有技术在处理基因缺失和高噪声方面的局限。研究表明，PASTA 在处理不同组织（如人肺癌和脑组织）的模拟与真实数据集时，其表现显著优于 Tangram 和 Seurat 等现有工具。通过对功能相关基因进行聚合建模，该工具不仅增强了数据的稳健性，还为下游的通路富集分析和细胞发育轨迹推断提供了更具生物学意义的解释。总之，PASTA 为在复杂的空间背景下理解疾病机制和组织异质性提供了一个强有力的学术方案。References: Li R, Yang P, Di Pilato M, et al. Accurate imputation of pathway-specific gene expression in spatial transcriptomics with PASTA[J]. Nature Communications, 2025.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
363-PASTA：基于通路导向的空间转录组基因表达填补方法
0:00
18:55
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 18 minutes long.
When was this 聊聊Sci episode published?
This episode was published on January 7, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!