EPISODE · Jan 7, 2026 · 17 MIN
364-基于拉曼染料成像与组织透明化的高通量体积映射
from 聊聊Sci
本文介绍了一种名为RADIANT的新型光学成像技术，旨在攻克复杂生物系统中多靶点蛋白质三维制图的难题。研究人员利用拉曼光谱极窄的峰宽打破了传统荧光显微镜的“色彩限制”，实现了在厚组织中单次捕获超过十种蛋白质信号。通过合成新型MARS生物正交探针并优化专用的rDISCO组织透明化技术，该方法成功解决了深层组织成像中的背景干扰与信号衰减问题。实验证明，RADIANT能对毫米级厚度的脑组织进行高分辨率成像，将探测深度提升了10至100倍。这一突破为探索发育生物学及神经系统中精细的三维蛋白质相互作用和神经网络拓扑结构提供了强大的工具。References: Shi, L., Wei, M., Miao, Y. et al. Highly-multiplexed volumetric mapping with Raman dye imaging and tissue clearing. Nat Biotechnol 40, 364–373 (2022). doi.org前往小宇宙评论区与主播互动
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364-基于拉曼染料成像与组织透明化的高通量体积映射
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