EPISODE · Jan 7, 2026 · 17 MIN
370-代谢压力对肝细胞及肝癌演化的影响
from 聊聊Sci
这项研究通过多组学分析深入探讨了肝细胞在长期慢性代谢压力（如肥胖和代谢功能障碍相关脂肪性肝病）下的演变过程。作者利用单细胞测序与空间转录组学技术，定义了小鼠和人类肝脏中随病程进展的基因表达程序，揭示了从单纯性脂肪变性到肝硬化及癌症的分子路径。研究重点识别并验证了RELB和SOX4等关键转录调节因子，这些因子不仅驱动了细胞的应激反应，还显著增强了肝细胞的增殖能力。通过构建MATCHA计算框架，研究者成功绘制了调节网络，证明了环境压力如何诱导肝细胞进入一种部分去分化的预癌变状态。最终，该研究为预测肝细胞癌的发生风险提供了生物标志物，并为干预慢性肝病向恶性肿瘤转化提供了潜在的治疗靶点。References: Tzouanas C N, Shay J E S, Sherman M S, et al. Hepatic adaptation to chronic metabolic stress primes tumorigenesis[J]. Cell, 2025.前往小宇宙评论区与主播互动
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370-代谢压力对肝细胞及肝癌演化的影响
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