381-声学报告基因:实现深层组织的多重超声成像 episode artwork

EPISODE · Jan 7, 2026 · 16 MIN

381-声学报告基因:实现深层组织的多重超声成像

from 聊聊Sci

这项研究开发了新型声学报告基因,首次实现了多重超声成像,能够同时观测活体深层组织中的多种细胞状态。科研人员通过蛋白质工程和定向进化技术,设计出具有不同声压响应特征的蛋白质纳米结构,并将其命名为 bARG560 和 bARG710。这些基因能够像荧光蛋白区分颜色一样,让研究者通过不同的超声频率或压力辨别不同的细胞群。实验成功在小鼠体内区分了益生菌种类,并实时监测了肿瘤定植细菌的分布情况。这一突破克服了光学成像穿透力差的局限,为深层生物组织的复杂功能研究提供了高分辨率的成像工具。该技术在细胞疗法追踪和活体分子诊断领域具有广阔的应用前景。References: Nyström N N, Jin Z, Bennett M E, et al. Multiplexed ultrasound imaging of gene expression[J]. Nature Methods, 2025: 1-7.前往小宇宙评论区与主播互动

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381-声学报告基因:实现深层组织的多重超声成像

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