EPISODE · Jan 15, 2026 · 19 MIN
397-人鼠肺纤维化空间转录组图谱比较研究
from 聊聊Sci
这项研究利用空间转录组学技术，对比分析了人类特发性肺纤维化（IPF）与小鼠博来霉素模型中肺部组织的基因表达差异。研究重点揭示了纤维化微环境中的异常基底样（AbBa）上皮细胞，并发现其在人类病变中呈现出一种非再生性的分化停滞状态。相比之下，小鼠模型显示出更强的肺泡修复能力，其肺泡二型细胞能通过过渡状态有效转化为一型细胞。此外，研究还通过配体-受体分析识别了TGF-β、APOE及Wnt等关键信号通路在驱动纤维化过程中的作用。这些发现强调了人类疾病与动物模型在组织重塑机制上的核心差异，为开发肺纤维化新疗法提供了重要的空间分子图谱。References: Franzén, L., Olsson Lindvall, M., Hühn, M. et al. Mapping spatially resolved transcriptomes in human and mouse pulmonary fibrosis. Nat Genet 56, 1725–1736 (2024). doi.org前往小宇宙评论区与主播互动
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397-人鼠肺纤维化空间转录组图谱比较研究
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