4 15 2024

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Alectinib in Resected ALK-Positive Non–Small-Cell Lung Cancer

Trial of Early Minimally Invasive Removal of Intracerebral Hemorrhage

  Journal of  American Medical Association

Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability

Single Ascending and Multiple-Dose Trial of Zerlasiran, a Short Interfering RNA Targeting Lipoprotein(a)

 Nature Medicine

Feasibility of functional precision medicine for guiding treatment of relapsed or refractory pediatric cancers

  British Medical Journal

Impact of large scale, multicomponent intervention to reduce proton pump inhibitor overuse in integrated healthcare system: difference-in-difference study

Efficacy of a single low dose of esketamine after childbirth for mothers with symptoms of prenatal depression: randomised clinical trial

  Lancet

Pembrolizumab or placebo with chemoradiotherapy followed by pembrolizumab or placebo for newly diagnosed, high-risk, locally advanced cervical cancer (ENGOT-cx11/GOG-3047/KEYNOTE-A18): a randomised, double-blind, phase 3 clinical trial

  Journal of Clinical Oncology

Genomic Classification and Individualized Prognosis in Multiple Myeloma

  journal of Hepatology

Long-term use of tenofovir disoproxil fumarate increases fracture risk in elderly patients with chronic hepatitis B

Episodic overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt does not increase mortality in patients with cirrhosis

 Clinical Gastroenterology

Significance of Crypt Atypia in Barrett’s Esophagus: A Clinical, Molecular, and Outcome Study

Liver Stiffness Measurement and Risk Prediction of Hepatocellular Carcinoma After HCV Eradication in Veterans With Cirrhosis

Dynamics of the Gut Mycobiome in Patients With Ulcerative Colitis

Benefits of Prokinetics, Gastroparesis Diet, or Neuromodulators Alone or in Combination for Symptoms of Gastroparesis

 Clinical Infectious Diseases

Raising AWaRe-ness of Antimicrobial Stewardship Challenges in Pediatric Emergency Care: Results from the PERFORM Study Assessing Consistency and Appropriateness of Antibiotic Prescribing Across Europe 

Treatment for First Cytomegalovirus Infection Post–Hematopoietic Cell Transplant in the AURORA Trial: A Multicenter, Double-Blind, Randomized, Phase 3 Trial Comparing Maribavir With Valganciclovir

SARS-CoV-2 Infection and Postacute Risk of Non–Coronavirus Disease 2019 Infectious Disease Hospitalizations: A Nationwide Cohort Study of Danish Adults Aged ≥50 Years

 Journal of infectious Diseases

 Journal of Clinical Rheumatology 

Chronic Nonbacterial Osteomyelitis Associated With Familial Mediterranean Fever in Children

  Arthritis and Rheumatology

Characterizing the Neurobiological Mechanisms of Action of Exercise and Cognitive–Behavioral Interventions for Rheumatoid Arthritis Fatigue: A Magnetic Resonance Imaging Brain Study

 Circulation

mPAP/CO Slope and Oxygen Uptake Add Prognostic Value in Aortic Stenosis

American College of Cardiology

One-Month Ticagrelor Monotherapy After PCI in Acute Coronary Syndromes

 Journals of the American College of Cardiology

Effectiveness of Clopidogrel vs Alternative P2Y12 Inhibitors Based on the ABCD-GENE Score

  Journal of Clinical Endocrinology & Metabolism

Signs of Glucagon Resistance After a 2-Week Hypercaloric Diet Intervention

Lifestyle Intervention With Smartphone App and isCGM for People at High Risk of Type 2 Diabetes: Randomized Trial

 Neurology:

Comparative Effectiveness of Natalizumab, Fingolimod, and Injectable Therapies in Pediatric-Onset Multiple Sclerosis: A Registry-Based Study

Association of Age-Related Neuropathologic Findings at Autopsy With a Claims-Based Epilepsy Diagnosis in Older Adults

 Chest

Symptoms and Impaired Quality of Life After COVID-19 Hospitalization: Effect of Therapeutic Heparin in Non-ICU Patients in the Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 Acute Trial

Use and Outcomes of Peripheral Vasopressors in Early Sepsis-Induced Hypotension Across Michigan Hospitals

The Effect of Pressure Changes During Mechanical Insufflation-Exsufflation on Respiratory and Airway Physiology

 The American Journal of Respiratory and Critical Care Medicine

SARS-CoV-2 Viral Replication Persists in the Human Lung for Several Weeks after Symptom Onset

  Clinical Journal of American Society of Nephrology

Efficacy of Voclosporin in Proliferative Lupus Nephritis with High Levels of Proteinuria

Monoclonal Gammopathy and Its Association with Progression to Kidney Failure and Mortality in Patients with CKD

 Kidney International reports

Implications of Implementing the 2021 CKD-EPI Equation Without Race on Managing Patients With Kidney Disease in British Columbia, Canada

Pregnancies in Women With Kidney Failure on Home Dialysis in the United States