4 15 2024

Hi, This Week in Medicine, we will be discussingNew England Journal of MedicineAlectinib in Resected ALK-Positive Non–Small-Cell Lung Cancer Trial of Early Minimally Invasive Removal of Intracerebral Hemorrhage  Journal of  American Medical AssociationAcetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability Single Ascending and Multiple-Dose Trial of Zerlasiran, a Short Interfering RNA Targeting Lipoprotein(a) Nature MedicineFeasibility of functional precision medicine for guiding treatment of relapsed or refractory pediatric cancers  British Medical JournalImpact of large scale, multicomponent intervention to reduce proton pump inhibitor overuse in integrated healthcare system: difference-in-difference study Efficacy of a single low dose of esketamine after childbirth for mothers with symptoms of prenatal depression: randomised clinical trial  LancetPembrolizumab or placebo with chemoradiotherapy followed by pembrolizumab or placebo for newly diagnosed, high-risk, locally advanced cervical cancer (ENGOT-cx11/GOG-3047/KEYNOTE-A18): a randomised, double-blind, phase 3 clinical trial  Journal of Clinical Oncology Genomic Classification and Individualized Prognosis in Multiple Myeloma  journal of HepatologyLong-term use of tenofovir disoproxil fumarate increases fracture risk in elderly patients with chronic hepatitis B Episodic overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt does not increase mortality in patients with cirrhosis Clinical GastroenterologySignificance of Crypt Atypia in Barrett’s Esophagus: A Clinical, Molecular, and Outcome Study Liver Stiffness Measurement and Risk Prediction of Hepatocellular Carcinoma After HCV Eradication in Veterans With Cirrhosis Dynamics of the Gut Mycobiome in Patients With Ulcerative Colitis Benefits of Prokinetics, Gastroparesis Diet, or Neuromodulators Alone or in Combination for Symptoms of Gastroparesis Clinical Infectious DiseasesRaising AWaRe-ness of Antimicrobial Stewardship Challenges in Pediatric Emergency Care: Results from the PERFORM Study Assessing Consistency and Appropriateness of Antibiotic Prescribing Across Europe  Treatment for First Cytomegalovirus Infection Post–Hematopoietic Cell Transplant in the AURORA Trial: A Multicenter, Double-Blind, Randomized, Phase 3 Trial Comparing Maribavir With Valganciclovir SARS-CoV-2 Infection and Postacute Risk of Non–Coronavirus Disease 2019 Infectious Disease Hospitalizations: A Nationwide Cohort Study of Danish Adults Aged ≥50 Years Journal of infectious Diseases Journal of Clinical Rheumatology Chronic Nonbacterial Osteomyelitis Associated With Familial Mediterranean Fever in Children  Arthritis and RheumatologyCharacterizing the Neurobiological Mechanisms of Action of Exercise and Cognitive–Behavioral Interventions for Rheumatoid Arthritis Fatigue: A Magnetic Resonance Imaging Brain Study CirculationmPAP/CO Slope and Oxygen Uptake Add Prognostic Value in Aortic Stenosis American College of Cardiology One-Month Ticagrelor Monotherapy After PCI in Acute Coronary Syndromes Journals of the American College of CardiologyEffectiveness of Clopidogrel vs Alternative P2Y12 Inhibitors Based on the ABCD-GENE Score  Journal of Clinical Endocrinology & MetabolismSigns of Glucagon Resistance After a 2-Week Hypercaloric Diet Intervention Lifestyle Intervention With Smartphone App and isCGM for People at High Risk of Type 2 Diabetes: Randomized Trial Neurology:Comparative Effectiveness of Natalizumab, Fingolimod, and Injectable Therapies in Pediatric-Onset Multiple Sclerosis: A Registry-Based Study Association of Age-Related Neuropathologic Findings at Autopsy With a Claims-Based Epilepsy Diagnosis in Older Adults ChestSymptoms and Impaired Quality of Life After COVID-19 Hospitalization: Effect of Therapeutic Heparin in Non-ICU Patients in the Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 Acute Trial Use and Outcomes of Peripheral Vasopressors in Early Sepsis-Induced Hypotension Across Michigan Hospitals The Effect of Pressure Changes During Mechanical Insufflation-Exsufflation on Respiratory and Airway Physiology The American Journal of Respiratory and Critical Care MedicineSARS-CoV-2 Viral Replication Persists in the Human Lung for Several Weeks after Symptom Onset  Clinical Journal of American Society of NephrologyEfficacy of Voclosporin in Proliferative Lupus Nephritis with High Levels of Proteinuria Monoclonal Gammopathy and Its Association with Progression to Kidney Failure and Mortality in Patients with CKD Kidney International reportsImplications of Implementing the 2021 CKD-EPI Equation Without Race on Managing Patients With Kidney Disease in British Columbia, Canada Pregnancies in Women With Kidney Failure on Home Dialysis in the United States