4 21 2025

Hi, This Week in Medicine, we will be discussingNew England Journal of MedicineEfficacy and Safety of Obinutuzumab in Active Lupus Nephritis Pulsed Field or Cryoballoon Ablation for Paroxysmal Atrial Fibrillation Fidanacogene Elaparvovec for Hemophilia B — A Multiyear Follow-up Study Journal of  American Medical AssociationUse of Life Support and Outcomes Among Patients Admitted to Intensive Care Units Annals of Internal MedicinePatterns of U.S. Firearm Injury Emergency Department Visits by Month, Day, and Time During 2018 to 2023 British Medical JournalFirearm availability and firearm incidents: quasi-experimental analysis using start of US hunting seasons  LancetEffect of invitation to colonoscopy versus faecal immunochemical test screening on colorectal cancer mortality (COLONPREV): a pragmatic, randomised, controlled, non-inferiority trial Journal of Clinical OncologyTrastuzumab-Pertuzumab Plus Eribulin or Taxane as First-Line Chemotherapy for Human Epidermal Growth Factor 2–Positive Locally Advanced/Metastatic Breast Cancer journal of HepatologyPNPLA3 rs738409, environmental factors and liver-related mortality in the US population Gastroenterology ERBB2 Comprehensive Profiling and Prognostication in Stage III Colon Cancer: Findings From PETACC8 and IDEA-France Cohorts  Clinical GastroenterologyHistological Outcomes of Pharmacological Interventions in Eosinophilic Esophagitis for Adults and Children: A Network Meta-analysis of Randomized Controlled Trials Rheumatology Osteoclastogenesis in Patients With Systemic Sclerosis With and Without Calcinosis Cutis  Journal of Clinical Rheumatology Childhood Familial Mediterranean Fever in the United States: Spectrum of Clinical Phenotypes and MEFV Genotypes in a Cohort From Southeast Michigan  Circulation Differential Associations of Cigar, Pipe, and Smokeless Tobacco Use Versus Combustible Cigarette Use With Subclinical Markers of Inflammation, Thrombosis, and Atherosclerosis: The Cross-Cohort Collaboration–Tobacco Working Group Journals of the American College of CardiologyGenetic Risk and First-Trimester Cardiovascular Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women JAMA CardiologyTreatment Strategies to Control Blood Pressure in People With Hypertension in Tanzania and LesothoA Randomized Clinical Trial Journal of Clinical Endocrinology & MetabolismEfficacy and Safety of TransCon PTH in Adults With Hypoparathyroidism: 52-Week Results From the Phase 3 PaTHway Trial Diabetes careLongitudinal Associations of PFAS Exposure With Insulin Sensitivity and β-Cell Function Among Hispanic Women With a History of Gestational Diabetes Mellitus  NeurologyInvestigating Whether Dissemination in Time Is Essential to Diagnose Relapsing Multiple Sclerosis  ChestSarcoidosis Treatment Patterns in the United States he American Journal of Respiratory and Critical Care MedicineNasal High Flow to Modulate Dyspnea in Orally Intubated PatientsKidney International reportsRandomized Trial of Lower-Dose Roxadustat Efficacy and Safety in Non–Dialysis-Dependent CKD-Associated Anemia Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan