4 21 2025

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis

Pulsed Field or Cryoballoon Ablation for Paroxysmal Atrial Fibrillation

Fidanacogene Elaparvovec for Hemophilia B — A Multiyear Follow-up Study

 Journal of  American Medical Association

Use of Life Support and Outcomes Among Patients Admitted to Intensive Care Units

 Annals of Internal Medicine

Patterns of U.S. Firearm Injury Emergency Department Visits by Month, Day, and Time During 2018 to 2023

 British Medical Journal

Firearm availability and firearm incidents: quasi-experimental analysis using start of US hunting seasons

  Lancet

Effect of invitation to colonoscopy versus faecal immunochemical test screening on colorectal cancer mortality (COLONPREV): a pragmatic, randomised, controlled, non-inferiority trial

 Journal of Clinical Oncology

Trastuzumab-Pertuzumab Plus Eribulin or Taxane as First-Line Chemotherapy for Human Epidermal Growth Factor 2–Positive Locally Advanced/Metastatic Breast Cancer

 journal of Hepatology

PNPLA3 rs738409, environmental factors and liver-related mortality in the US population

 Gastroenterology

ERBB2 Comprehensive Profiling and Prognostication in Stage III Colon Cancer: Findings From PETACC8 and IDEA-France Cohorts

  Clinical Gastroenterology

Histological Outcomes of Pharmacological Interventions in Eosinophilic Esophagitis for Adults and Children: A Network Meta-analysis of Randomized Controlled Trials

 Rheumatology 

Osteoclastogenesis in Patients With Systemic Sclerosis With and Without Calcinosis Cutis

  Journal of Clinical Rheumatology 

Childhood Familial Mediterranean Fever in the United States: Spectrum of Clinical Phenotypes and MEFV Genotypes in a Cohort From Southeast Michigan

  Circulation

 Differential Associations of Cigar, Pipe, and Smokeless Tobacco Use Versus Combustible Cigarette Use With Subclinical Markers of Inflammation, Thrombosis, and Atherosclerosis: The Cross-Cohort Collaboration–Tobacco Working Group

 Journals of the American College of Cardiology

Genetic Risk and First-Trimester Cardiovascular Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women

 JAMA Cardiology

Treatment Strategies to Control Blood Pressure in People With Hypertension in Tanzania and LesothoA Randomized Clinical Trial

 Journal of Clinical Endocrinology & Metabolism

Efficacy and Safety of TransCon PTH in Adults With Hypoparathyroidism: 52-Week Results From the Phase 3 PaTHway Trial

 Diabetes care

Longitudinal Associations of PFAS Exposure With Insulin Sensitivity and β-Cell Function Among Hispanic Women With a History of Gestational Diabetes Mellitus 

 Neurology

Investigating Whether Dissemination in Time Is Essential to Diagnose Relapsing Multiple Sclerosis

  Chest

Sarcoidosis Treatment Patterns in the United States

 he American Journal of Respiratory and Critical Care Medicine

Nasal High Flow to Modulate Dyspnea in Orally Intubated Patients

Kidney International reports

Randomized Trial of Lower-Dose Roxadustat Efficacy and Safety in Non–Dialysis-Dependent CKD-Associated Anemia

Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan