4 7 2025

Hi, This Week in Medicine, we will be discussing

 New England Journal of Medicine

Twice-Yearly Lenacapavir for HIV Prevention in Men and Gender-Diverse Persons

Left Atrial Appendage Closure after Ablation for Atrial Fibrillation

Alteplase for Posterior Circulation Ischemic Stroke at 4.5 to 24 Hours

The Genetic Architecture of Congenital Diarrhea and Enteropathy

 Journal of  American Medical Association

Cardiac Arrest During Long-Distance Running Races

 Annals of Internal Medicine

The Effect of 4:3 Intermittent Fasting on Weight Loss at 12 Months: A Randomized Clinical Trial

 British Medical Journal

Effects of intensive blood pressure treatment on orthostatic hypertension

 Lancet

Pharmacokinetics and safety of once-yearly lenacapavir: a phase 1, open-label study

 Journal of Clinical Oncology

Efficacy and Safety of Denileukin Diftitox-Cxdl, an Improved Purity Formulation of Denileukin Diftitox, in Patients With Relapsed or Refractory Cutaneous T-Cell Lymphoma

  journal of Hepatology

Association of metabolic signatures of air pollution with MASLD: Observational and Mendelian randomization study

 Gastroenterology

Glepaglutide, a Long-Acting Glucagon-like Peptide-2 Analogue, Reduces Parenteral Support in Patients With Short Bowel Syndrome: A Phase 3 Randomized Controlled Trial

 Clinical Gastroenterology

Preinjection With Ligation-Assisted Endoscopic Mucosal Resection for Barrett’s Dysplasia and Early Esophageal Adenocarcinoma: Characteristic Histological Features of the Depth of Resection

   Clinical Infectious Diseases

Peer-Assisted Telemedicine for Hepatitis C in People Who Use Drugs: A Randomized Controlled Tria

  Rheumatology 

Osteoclastogenesis in Patients With Systemic Sclerosis With and Without Calcinosis Cutis

  Journal of Clinical Rheumatology 

Age-Related Differences Between Juvenile and Adult Autoimmune Inflammatory Myopathies

  Circulation

Clinical Outcomes With Normothermic Pulsatile Organ Perfusion in Heart Transplantation: A Report From the OCS Heart Perfusion Registry

  Journals of the American College of Cardiology

New Threshold for Defining Mild Aortic Stenosis Derived From Velocity-Encoded MRI in 60,000 Individuals

  JAMA Cardiology

Intravascular Sympathetic Stimulation to Facilitate Catheter Ablation of Premature Ventricular Complexes

  Journal of Clinical Endocrinology & Metabolism

MBX 2109, A Once-Weekly Parathyroid Hormone Replacement Therapy Prodrug

 Diabetes care

Diabetes Risk After Treatment for Childhood and Young Adult Cancer 

  Neurology

Associations of Plasma Neurofilament Light Levels With Brain Microstructure and Macrostructure and Cognition in the Community-Based Rhineland Study

  Chest

Implementation and Effectiveness of Guideline-Recommended Clinical Activities for Children With Asthma

 The American Journal of Respiratory and Critical Care Medicine

Temporal Exploration of Chronic Obstructive Pulmonary Disease Phenotypes: Insights from the COPDGene and SPIROMICS Cohorts

 Clinical Journal of American Society of Nephrology

Performance of Creatinine and Cystatin-Based Equations on Estimating Measured GFR in People with Hematological and Solid Cancers

  Kidney International reports

Systematic Review of the Effects of Iron on Cardiovascular, Kidney, and Safety Outcomes in Patients With CKD