4 7 2025

Hi, This Week in Medicine, we will be discussing New England Journal of MedicineTwice-Yearly Lenacapavir for HIV Prevention in Men and Gender-Diverse Persons Left Atrial Appendage Closure after Ablation for Atrial Fibrillation Alteplase for Posterior Circulation Ischemic Stroke at 4.5 to 24 Hours The Genetic Architecture of Congenital Diarrhea and Enteropathy Journal of  American Medical AssociationCardiac Arrest During Long-Distance Running Races Annals of Internal MedicineThe Effect of 4:3 Intermittent Fasting on Weight Loss at 12 Months: A Randomized Clinical Trial British Medical JournalEffects of intensive blood pressure treatment on orthostatic hypertension LancetPharmacokinetics and safety of once-yearly lenacapavir: a phase 1, open-label study Journal of Clinical OncologyEfficacy and Safety of Denileukin Diftitox-Cxdl, an Improved Purity Formulation of Denileukin Diftitox, in Patients With Relapsed or Refractory Cutaneous T-Cell Lymphoma  journal of HepatologyAssociation of metabolic signatures of air pollution with MASLD: Observational and Mendelian randomization study Gastroenterology Glepaglutide, a Long-Acting Glucagon-like Peptide-2 Analogue, Reduces Parenteral Support in Patients With Short Bowel Syndrome: A Phase 3 Randomized Controlled Trial Clinical Gastroenterology Preinjection With Ligation-Assisted Endoscopic Mucosal Resection for Barrett’s Dysplasia and Early Esophageal Adenocarcinoma: Characteristic Histological Features of the Depth of Resection   Clinical Infectious DiseasesPeer-Assisted Telemedicine for Hepatitis C in People Who Use Drugs: A Randomized Controlled Tria  Rheumatology Osteoclastogenesis in Patients With Systemic Sclerosis With and Without Calcinosis Cutis  Journal of Clinical Rheumatology Age-Related Differences Between Juvenile and Adult Autoimmune Inflammatory Myopathies  CirculationClinical Outcomes With Normothermic Pulsatile Organ Perfusion in Heart Transplantation: A Report From the OCS Heart Perfusion Registry  Journals of the American College of CardiologyNew Threshold for Defining Mild Aortic Stenosis Derived From Velocity-Encoded MRI in 60,000 Individuals  JAMA CardiologyIntravascular Sympathetic Stimulation to Facilitate Catheter Ablation of Premature Ventricular Complexes  Journal of Clinical Endocrinology & MetabolismMBX 2109, A Once-Weekly Parathyroid Hormone Replacement Therapy Prodrug Diabetes careDiabetes Risk After Treatment for Childhood and Young Adult Cancer   NeurologyAssociations of Plasma Neurofilament Light Levels With Brain Microstructure and Macrostructure and Cognition in the Community-Based Rhineland Study  ChestImplementation and Effectiveness of Guideline-Recommended Clinical Activities for Children With Asthma The American Journal of Respiratory and Critical Care MedicineTemporal Exploration of Chronic Obstructive Pulmonary Disease Phenotypes: Insights from the COPDGene and SPIROMICS Cohorts Clinical Journal of American Society of NephrologyPerformance of Creatinine and Cystatin-Based Equations on Estimating Measured GFR in People with Hematological and Solid Cancers  Kidney International reportsSystematic Review of the Effects of Iron on Cardiovascular, Kidney, and Safety Outcomes in Patients With CKD