4 8 2024

Hi, This Week in Medicine, we will be discussing

 New England Journal of Medicine

Omitting Axillary Dissection in Breast Cancer with Sentinel-Node Metastases

Trial of Lixisenatide in Early Parkinson’s Disease

Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19

Pragmatic Trial of Hospitalization Rate in Chronic Kidney Disease

 Journal of  American Medical Association

Prostate-Specific Antigen Screening and 15-Year Prostate Cancer Mortality: A Secondary Analysis of the CAP Randomized Clinical Trial

Single Ascending and Multiple-Dose Trial of Zerlasiran, a Short Interfering RNA Targeting Lipoprotein(a)

 Annals of Internal Medicine

Association of Low Glomerular Filtration Rate With Adverse Outcomes at Older Age in a Large Population With Routinely Measured Cystatin C

  Nature Medicine

Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial

 British Medical Journal

Use of progestogens and the risk of intracranial meningioma: national case-control study

 Lancet

Coronary sinus reducer for the treatment of refractory angina (ORBITA-COSMIC): a randomised, placebo-controlled trial

 Journal of Clinical Oncology

Lenvatinib Plus Pembrolizumab Versus Sunitinib in First-Line Treatment of Advanced Renal Cell Carcinoma: Final Prespecified Overall Survival Analysis of CLEAR, a Phase III Study

  journal of Hepatology

Preventing liver disease with policy measures to tackle alcohol consumption and obesity: The HEPAHEALTH II study

Effects of tetrathiomolybdate on copper metabolism in healthy volunteers and in patients with Wilson disease

  Clinical Gastroenterology

The Index of Severity for Eosinophilic Esophagitis (I-SEE) Reflects Longitudinal Clinicopathologic Changes in Children

Alcoholic Foamy Degeneration, an Entity Resembling Alcohol-Associated Hepatitis: Diagnosis, Prognosis, and Molecular Profiling

Modified-Release Phosphatidylcholine (LT-02) for Ulcerative Colitis: Two Double-Blind, Randomized, Placebo-Controlled Trials

Quality of Life and Bidirectional Gut-Brain Interactions in Irritable Bowel Syndrome From Adolescence to Adulthood

 Clinical liver disease

Acceptability of hepatitis C screening and treatment during pregnancy in pregnant women in Egypt, Pakistan, and Ukraine: A cross-sectional survey

  Clinical Infectious Diseases

Is Short-Course Antibiotic Therapy Suitable for Pseudomonas aeruginosa Bloodstream Infections in Onco-hematology Patients With Febrile Neutropenia? Results of a Multi-institutional Analysis

Bartonella quintana Endocarditis: A Systematic Review of Individual Cases

Socioeconomic and Demographic Risk Factors for SARS-CoV-2 Seropositivity Among Healthcare Workers in a UK Hospital: A Prospective Cohort Study

  Journal of infectious Diseases

Effectiveness of BNT162b2 BA.4/5 Bivalent mRNA Vaccine Against Symptomatic COVID-19 Among Immunocompetent Individuals Testing at a Large US Retail Pharmacy 

 Journal of Clinical Rheumatology 

Transition From Pediatric to Adult Rheumatology Care: An Exploratory Study From Latin America

  Arthritis and Rheumatology

Poly-Refractory Rheumatoid Arthritis: An Uncommon Subset of Difficult to Treat Disease With Distinct Inflammatory and Noninflammatory Phenotypes

 Circulation

Clinical and Prognostic Implications of Right Ventricular Uptake on Bone Scintigraphy in Transthyretin Amyloid Cardiomyopathy

American College of Cardiology

 Journals of the American College of Cardiology

Variation in Health Status With Invasive vs Conservative Management of Chronic Coronary Disease

 Journal of Clinical Endocrinology & Metabolism

Effect and Interactions of BRAF on Lymph Node Metastasis in Papillary Thyroid Carcinoma With Hashimoto Thyroiditi

Metabolic Profiles of Type 2 Diabetes and Their Association With Renal Complications

Next we will be discussing articles  from Neurology:

Remote Ischemic Conditioning With Medical Management or Reperfusion Therapy for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

Statin Initiation and Risk of Incident Alzheimer Disease and Cognitive Decline in Genetically Susceptible Older Adults

  Chest

Use of Quantitative CT Imaging to Identify Bronchial Thermoplasty Responders

Individual Risk Factors of PM2.5 Associated With Wintertime Mortality in Urban Patients With COPD

High-Resolution CT Scan Fibrotic Patterns in Stage IV Pulmonary Sarcoidosis

 The American Journal of Respiratory and Critical Care Medicine

Antimicrobial Drug Penetration Is Enhanced by Lung Tissue Inflammation and Injury

 Clinical Journal of American Society of Nephrology

.

Strategies to Guide Preemptive Waitlisting and Equity in Waittime Accrual by Race/Ethnicity

Association of eGFR and Albuminuria with Venous Thromboembolism

  Kidney International reports

Acute Kidney Injury Duration and 20-Year Risks of CKD and Cardiovascular Disease

Systematic Review of Women Leading and Participating in Nephrology Randomized Clinical Trials