#41 | GMJ Podcast | Hydrochemical Stability and Radiobiology of Tskaltubo Mineral Water — Clinical and Scientific Evaluation

In this episode of the ⁠GMJ Podcast — the official podcast of the Georgian Medical Journal⁠ — we present a comprehensive scientific analysis of Tskaltubo mineral water, focusing on its hydrochemical stability, low-dose alpha radiobiology, and nitrogen-mediated neurovascular effects.Tskaltubo mineral water has long been recognized for its therapeutic use in balneotherapy. This episode examines the scientific basis behind its clinical applications, exploring how its unique composition may influence physiological processes, including vascular regulation, neural signaling, and systemic adaptation.The discussion highlights emerging evidence on the biological effects of low-dose alpha radiation and dissolved gases, particularly nitrogen, and their potential role in modulating neurovascular function and rehabilitation outcomes.The episode examines key scientific and clinical considerations, including:• Hydrochemical composition and long-term stability of Tskaltubo mineral water• Mechanisms of low-dose alpha radiobiology and adaptive responses• The role of nitrogen in neurovascular modulation• Potential therapeutic applications in rehabilitation and chronic conditions• Integration of balneotherapy into modern evidence-based medicine• Limitations of current evidence and need for further clinical validationThe findings suggest that while traditional therapeutic use is well established, modern scientific evaluation provides a deeper understanding of potential mechanisms underlying observed clinical effects. However, further high-quality clinical research is required to confirm efficacy and define standardized therapeutic protocols.This episode highlights the importance of integrating traditional therapeutic practices with contemporary scientific validation, ensuring safe, evidence-based application within modern healthcare systems.https://gmj.ge/index.php/pub/article/view/35Citation:Shavianidze, M., & Lomidze, G. (2026). Hydrochemical Stability, Low-Dose Alpha Radiobiology and Nitrogen-Mediated Neurovascular Modulation: A Comprehensive Scientific Evaluation of Tskaltubo Mineral Water. The Georgian Medical Journal.