41. The Truth About Oral Estradiol And HRT For Women episode artwork

EPISODE · Sep 3, 2025 · 16 MIN

41. The Truth About Oral Estradiol And HRT For Women

from The HRT University® Podcast · host Nico Misleh

Is the fear around oral estradiol and blood clots actually based on outdated, flawed science? For years, providers have been told to avoid oral estradiol due to the perceived risk of clots, strokes, and cancer, but the largest, most powerful studies, including recent randomized control trials from 2022, tell a completely different story. In episode 41 of the Nico Misleh Podcast, host Nico Misleh dismantles this common medical myth, revealing how oral estradiol is not only safe but offers significant benefits for bone health, heart disease, and lipid profiles that transdermal options simply don't provide. Learn the truth about first pass metabolism and why it's a feature, not a bug, for helping your patients achieve incredible outcomes.Ready to confidently prescribe HRT based on the latest evidence, not fear? Join the HRT University Master Course and gain the clinical mastery to build the profitable, purpose-driven practice you and your patients deserve. Sign up now: https://hrtuniversity.com/hrtcourse/⁠For practitioners who want to confidently grow their practice with guidance in TRT, HRT, and business strategy, find us below:- Nico's Daily Newsletter: ⁠⁠⁠https://nicomislenp.kit.com/8050eeea5f⁠⁠⁠ (yes, it's daily... and yes, people stay subscribed)- Join HRT University: ⁠https://hrtuniversity.com/⁠- Join the HRT University Facebook Group: ⁠⁠⁠https://www.facebook.com/groups/1179376819949373/?ref=share&_rdr⁠Chapters:0:00 The #1 Myth About Estrogen 1:01 Why Your Colleagues Are Scared of This 1:54 The Flawed Study Everyone Believes 3:17 Proof: 10 Years of Research Says THIS 4:48 A Brand New Study from 2022 6:53 The Missing Piece of The Puzzle 8:52 Why Oral Is Better Than Patches 10:36 The "Problem" Is Actually a Feature 11:59 How to Stop Fearing HRT 12:39 The Question Every Great Provider Asks 14:22 Get Patients Amazing Results (And Get Paid) 15:35 My Gift To You (FREE Resources)

Is the fear around oral estradiol and blood clots actually based on outdated, flawed science? For years, providers have been told to avoid oral estradiol due to the perceived risk of clots, strokes, and cancer, but the largest, most powerful studies, including recent randomized control trials from 2022, tell a completely different story. In episode 41 of the Nico Misleh Podcast, host Nico Misleh dismantles this common medical myth, revealing how oral estradiol is not only safe but offers significant benefits for bone health, heart disease, and lipid profiles that transdermal options simply don't provide. Learn the truth about first pass metabolism and why it's a feature, not a bug, for helping your patients achieve incredible outcomes.Ready to confidently prescribe HRT based on the latest evidence, not fear? Join the HRT University Master Course and gain the clinical mastery to build the profitable, purpose-driven practice you and your patients deserve. Sign up now: https://hrtuniversity.com/hrtcourse/⁠For practitioners who want to confidently grow their practice with guidance in TRT, HRT, and business strategy, find us below:- Nico's Daily Newsletter: ⁠⁠⁠https://nicomislenp.kit.com/8050eeea5f⁠⁠⁠ (yes, it's daily... and yes, people stay subscribed)- Join HRT University: ⁠https://hrtuniversity.com/⁠- Join the HRT University Facebook Group: ⁠⁠⁠https://www.facebook.com/groups/1179376819949373/?ref=share&_rdr⁠Chapters:0:00 The #1 Myth About Estrogen 1:01 Why Your Colleagues Are Scared of This 1:54 The Flawed Study Everyone Believes 3:17 Proof: 10 Years of Research Says THIS 4:48 A Brand New Study from 2022 6:53 The Missing Piece of The Puzzle 8:52 Why Oral Is Better Than Patches 10:36 The "Problem" Is Actually a Feature 11:59 How to Stop Fearing HRT 12:39 The Question Every Great Provider Asks 14:22 Get Patients Amazing Results (And Get Paid) 15:35 My Gift To You (FREE Resources)

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41. The Truth About Oral Estradiol And HRT For Women

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This episode was published on September 3, 2025.

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Is the fear around oral estradiol and blood clots actually based on outdated, flawed science? For years, providers have been told to avoid oral estradiol due to the perceived risk of clots, strokes, and cancer, but the largest, most powerful...

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