EPISODE · Jan 21, 2026 · 18 MIN
412-CLINK：高密度细胞链接生物打印技术
from 聊聊Sci
这项研究开发了一种名为 CLINK 的创新型生物打印技术，通过使用特殊的 OMHA 分子连接器 直接对细胞表面进行修饰。该技术突破了传统生物打印中细胞密度低且过度依赖生物材料支架的局限，能够制造出高达 10^9 cells/mL 的超高密度组织模型。利用数字光处理（DLP）打印技术，研究人员成功构建了功能性的神经回路、搏动的心脏微缩模型以及具有血管通道的肝脏切片。实验证明，这些支架极简化或无支架的结构具有极佳的生物相容性和功能性，能显著促进活体内的组织再生与伤口愈合。这一成果为疾病建模、药物筛选及再生医学提供了一种高度精确且具有临床应用潜力的标准化平台。References: Wang M, Li W, Hao J, et al. Biomaterial-minimalistic photoactivated bioprinting of cell-dense tissues[J]. Cell, 2026, 189(1): 106-122. e26.前往小宇宙评论区与主播互动
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412-CLINK：高密度细胞链接生物打印技术
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