EPISODE · Jan 21, 2026 · 16 MIN
413-泛素化调控TREX1降解与肿瘤免疫反应
from 聊聊Sci
这项研究探讨了前列腺癌如何通过SPOP基因突变逃避免疫系统的监测，并提出了一种联合治疗方案。研究发现，正常的SPOP蛋白能通过泛素化降解TREX1酶，从而促进细胞质内DNA积累并激活cGAS-STING免疫通路。然而，SPOP突变会导致TREX1异常堆积，迅速清除受损DNA，使肿瘤细胞即便在放射治疗后也无法触发免疫反应。为解决这一问题，研究者证明使用USP7抑制剂可以恢复TREX1的降解，增强肿瘤的免疫原性。最终实验证实，将USP7抑制剂、放射治疗与**免疫检查点阻断（ICB）**相结合，能显著提升前列腺癌的治疗效果并提高生存率。References: Li L, Ye Q, Ma J, et al. Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage[J]. Cancer Cell, 2026.前往小宇宙评论区与主播互动
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413-泛素化调控TREX1降解与肿瘤免疫反应
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