EPISODE · Jan 22, 2026 · 18 MIN
414-IGLL5+ B细胞破坏三级淋巴结构并抑制肿瘤免疫回复
from 聊聊Sci
这项发表在《Cancer Cell》上的研究揭示了IGLL5+ B细胞子集在膀胱癌及多种癌症中破坏三级淋巴结构（TLS）并导致免疫治疗耐药的机制。研究人员通过单细胞测序和空间转录组技术发现，此类B细胞通过IGLL5-LTβR配体-受体相互作用锚定于高内皮静脉（HEVs），进而抑制其非经典NF-κB信号通路，导致HEV功能障碍和TLS解体。这种结构的破坏阻碍了效应CD8+ T细胞的激活，使肿瘤产生免疫逃逸。临床实验表明，使用IGLL5中和抗体可有效恢复TLS形成，显著增强免疫检查点阻断疗法的疗效。该成果为攻克肿瘤免疫治疗耐药提供了全新的治疗靶点和策略。References: Chen C, An M, Zheng H, et al. B cells disrupt tertiary lymphoid structure formation and suppress anti-tumor immunity[J]. Cancer Cell, 2026.前往小宇宙评论区与主播互动
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414-IGLL5+ B细胞破坏三级淋巴结构并抑制肿瘤免疫回复
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