#42 - Circadian rhythms, exercise and type 2 diabetes with Dr Juleen Zierath

Dr Glenn McConell chats with Professor Juleen Zierath who has had a remarkable background with current senior roles at both the Karolinska Institute in Sweden and the University of Copenhagen in Denmark. She was also previously the Chair of the Nobel Committee. We discuss the effects of circadian rhythms on: muscle insulin sensitivity, metabolic responses to exercise in T2D vs controls, exercise performance, metabolism in men vs women and integrative physiology. A very interesting chat. Twitter: @JuleenRZierath. 0:00. Introduction and Juleen’s academic and research background 7:39. Ball State University and David “Doc” Costill 9:40. What it’s like on the Nobel Prize committee 15:00. Circadian rhythms and physiology/metabolism/exercise 18:50. Metabolic flexibility, circadian biology and exercise 19:50. Central and peripheral clocks etc. 23:55. Jet lag and light/clocks 24:25. Different experimental models: Insects, mice and humans 27:53. Circadian misalignments in obesity and diabetes 29:02. Genetics + environment re obesity, insulin sensitivity 30:06. Circadian rhythms in muscle cells 32:40. Exercise: can it cure type 2 diabetes? 35:32. Genes matter 35:42. Shift work and insulin resistance / cancer 36:46. Hyperglycemia after morning not afternoon exercise (CGMs) 43:50. Mortality and the time of exercise 44:56. Effect of the time of day on exercise performance 46:18. Sex differences: exercise, inflammation and the genome 50:37. Controversies?: we don’t know enough/more to learn 53:43. Takeaway messages 56:09. Outro (9 secs) Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all. The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University. He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9). Connect with Inside Exercise and Glenn McConell at: Twitter: @Inside_exercise and @GlennMcConell1 Instagram: insideexercise Facebook: Glenn McConell LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460 ResearchGate: Glenn McConell Email: [email protected] Subscribe to Inside exercise: Spotify: shorturl.at/tyGHL Apple Podcasts: shorturl.at/oFQRU YouTube: https://www.youtube.com/@insideexercise Anchor: https://anchor.fm/insideexercise Google Podcasts: shorturl.at/bfhHI Anchor: https://anchor.fm/insideexercise Podcast Addict: https://podcastaddict.com/podcast/4025218 Not medical advice