EPISODE · Jan 23, 2026 · 16 MIN
422-系统单细胞图谱：形态发生素对神经类器官的影响
from 聊聊Sci
这项研究利用单细胞转录组学技术，系统地分析了多种形态发生素（如SHH、FGF8、RA等）在不同时间和浓度下如何影响人类脑类器官的区域化发育。研究人员开发了大规模筛选方法，揭示了调节神经图式形成的关键基因调控网络（regulons），并对比了传统类器官与具有组织结构的MiSTR模型在响应信号分子时的差异。实验发现，调节因子的加入时机与剂量能够精确引导细胞向端脑、下丘脑或后脑等特定大脑区域分化。研究还指出，细胞系之间的遗传差异和培养环境的物理约束会显著影响神经图式的生成效果。该工作为优化体外神经模型提供了重要资源，有助于更准确地模拟人类中枢神经系统的早期发育过程。References: Sanchís-Calleja F, Azbukina N, Jain A, et al. Systematic scRNA-seq screens profile neural organoid response to morphogens[J]. Nature Methods, 2025: 1-14.前往小宇宙评论区与主播互动
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422-系统单细胞图谱：形态发生素对神经类器官的影响
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