EPISODE · Jan 25, 2026 · 18 MIN
430-Cas12a3核酸酶通过切割tRNA尾部防御噬菌体
from 聊聊Sci
这些材料介绍了一种新型的 CRISPR-Cas12a3 免疫防御机制，它通过破坏 tRNA 来阻止病毒复制。研究发现，当该系统识别出特定的病毒序列后，会激活其核酸酶活性，专门剪切 tRNA 端的 3' CCA 序列。这种精确的切割会导致细胞内的蛋白质合成全面停滞，从而限制病毒的扩散。与传统的 CRISPR 系统不同，Cas12a3 表现出对 tRNA 的高度选择性，而不是无差别地降解所有 RNA。这种独特的防御策略不仅扩展了我们对细菌适应性免疫的认知，也为开发新型生物技术工具提供了可能。研究人员通过冷冻电镜技术和生化实验，详细揭示了该蛋白质与其目标分子相互作用的分子结构基础。References: Dmytrenko O, Yuan B, Crosby K T, et al. RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity[J]. Nature, 2026: 1-10.前往小宇宙评论区与主播互动
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430-Cas12a3核酸酶通过切割tRNA尾部防御噬菌体
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