434-微藻益生菌杂交机器人治疗炎症性肠病 episode artwork

EPISODE · Jan 26, 2026 · 15 MIN

434-微藻益生菌杂交机器人治疗炎症性肠病

from 聊聊Sci

这项研究介绍了一种专为炎症性肠病(IBD)治疗设计的口服生物混合微型机器人。该机器人由经过压力训练的雨生红球藻、益生菌以及特殊的肠道制动系统组成,能够有效克服胃酸侵蚀并精准送达病灶。通过压力预处理,微藻不仅外壳增厚以抵御酸性环境,还能够大量合成具有强效抗氧化作用的虾青素。聚多巴胺(PDA)涂层则赋予了机器人“刹车”功能,使其能牢固黏附在肠道炎症部位,实现药物的长效释放。实验证明,该系统通过清除活性氧(ROS)和调节肠道菌群,显著改善了小鼠的结肠炎症状。这种结合了自主运动能力与智能靶向黏附的创新方案,为临床治疗多种胃肠道疾病提供了新的思路。References: Luo R, Liu J, Dai L, et al. Stress-trained microalgae robots with probiotics backpack and intestinal brake for inflammatory bowel disease management[J]. Nature Communications, 2026.前往小宇宙评论区与主播互动

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434-微藻益生菌杂交机器人治疗炎症性肠病

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