#446 Dr Lauren Colenso-Semple - Wellness Peptides and Differences Between Men’s and Women’s Training

Dr Lauren Colenso-Semple is back to tackle a series of current trends, narratives, and pseudoscientific claims in fitness and wellness, including:-Is there any quality human research on “wellness peptides”-What are wellness peptides-Why are they becoming more popular-Is there any evidence to suggest that muscle building is any different for women than men-Is there any evidence that birth control affects muscle growth-Is there any difference in protein timing needs for muscle growth in women-Are there notable differences in muscle fibre type between men and women-Is there any association between testosterone levels and lean mass and strength in women-Does menopause accelerate muscle loss-Is creatine as potent as it’s currently hyped-Is there any evidence to support cycle syncing-Why is messaging around unique physiological differences so appealing to women-Why are some fitness and wellness “professionals” incentivized to brand around differences in men’s and women’s training physiology-Are there differences in injury risks across the phases of menstrual cycles-Do vibration plates have any benefits-Is calling out female creators for spreading misinformation by other women “mean girl behaviour”-And much moreIG: @drlaurencs1CHAPTERS01:00 What Are Wellness Peptides and Why They’re Trending02:00 How Peptides Work in the Body03:00 Drug Development and Approval Process04:00 Unapproved Peptides in the Wellness Market07:00 Biological Risks and Tumor Concerns08:00 Limited Human Data and Research Quality09:00 Placebo Effects and Pain Resolution10:00 Drug Approval vs Evidence Reality11:00 Placebo Surgery Example and Mind-Body Effects12:00 The “Wild West” of Peptide Research13:00 Manufacturing and Dosing Risks14:00 Why Peptides Became Popular15:00 Normalization of Injectables and “Natural” Marketing20:00 Branding Differences Between Approved Drugs and Peptides24:00 Historical Drug Regulation Context25:00 Are Muscle Gains Different Between Men and Women?26:00 Molecular and Physiological Similarities Between Sexes27:00 Muscle Fiber Type Complexity30:00 Genetics vs Training Adaptation33:00 Athlete Caliber vs Sex Differences37:00 Creatine Performance Effects38:00 Creatine and Clinical Populations39:00 High Dose Creatine Considerations42:00 Testosterone Myths and Hypertrophy43:00 Menopause and Muscle Loss45:00 Measuring Testosterone and Lab Variability46:00 PCOS and Testosterone Levels47:00 Research Gaps in PCOS and Performance48:00 Menstrual Cycle Strength Research Discussion51:00 Why Cycle Syncing Messaging Is Appealing52:00 Marketing Incentives and Female Targeting53:00 Diet Culture Parallel and Behavior Change54:00 Individualization vs Simple Prescriptions55:00 Age vs Training Factors That Actually Matter58:00 Vibration Plates — Claims vs Evidence59:00 Exercise vs Passive Modalities01:01:00 Injury Risk Across Menstrual Cycle PhasesSUPPORT THE SHOWIf this episode helped you cut through confusion in fitness and wellness claims, you can support the show by:• Subscribing and checking out more episodes• Sharing it on your social media (tag me — I’ll respond)• Sending it to a friend who’s overwhelmed by conflicting adviceFOLLOW ANDREW COATESInstagram: @andrewcoatesfitnesshttps://www.andrewcoatesfitness.comPARTNERS AND RESOURCESRP Strength App (use code COATESRP)https://www.rpstrength.com/coatesJust Bite Me Meals (use code ANDREWCOATESFITNESS for 10% off)https://justbitememeals.comMacrosFirst – FREE Premium TrialDownload MacrosFirst and during setup you’ll be asked “How did you hear about us?”Type in: ANDREWKNKG Bags (15% off)https://www.knkg.com/Andrew59676Versa Gripps (discount link)https://www.versagripps.com/andrewcoatesTRAINHEROIC – FREE 90-Day TRIAL (2 steps)Go to https://www.trainheroic.com/liftfreeReply to the email you receive (or email [email protected]) and let them know Andrew sent you