EPISODE · Jan 30, 2026 · 16 MIN
446-中西合璧：中子搭便车纳米囊泡治疗细菌感染
from 聊聊Sci
这项研究开发了一种名为 PMB@LNV-SyBV 的新型多功能杂化纳米囊泡，旨在攻克耐药性细菌感染治疗。该平台由具有抗炎作用的柠檬来源外泌体 (LNVs) 与经过减毒处理的合成细菌囊泡 (SyBV) 融合而成，并利用外源性胆固醇增强了药物多粘菌素 B (PMB) 的负载能力。这种杂化囊泡能够通过“中性粒细胞搭便车”策略，利用免疫细胞的自然趋化性精准到达炎症和感染部位。实验证明，该系统能显著降低肺炎及败血症模型小鼠体内的细菌负荷，同时有效抑制促炎细胞因子的释放。凭借良好的生物相容性和高产量，这种仿生递送系统为临床治疗碳青霉烯耐药菌感染提供了一种极具潜力的新方案。References: Li H, Yan H, Xiong J, et al. Neutrophil-mediated delivery of hybrid cross-species nanovesicles for treatment of bacterial infections[J]. Nature Communications, 2025.前往小宇宙评论区与主播互动
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446-中西合璧：中子搭便车纳米囊泡治疗细菌感染
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