EPISODE · Jan 31, 2026 · 16 MIN
452-肠道神经胶质细胞多样性与TACR3信号调控
from 聊聊Sci
这项研究揭示了肠道神经系统中神经胶质细胞的分子多样性及其对肠道蠕动的调控机制。研究人员通过转录组测序技术，将肠道胶质细胞划分为粘膜层和肌层两大功能独特的种群，并构建了基于空间定位的分子图谱。实验发现，速激肽信号通路（NKB-TACR3）是驱动这些细胞在发育过程中实现多样化的关键因素。在功能上，TACR3受体主要表达于肌间神经节内的胶质细胞，作为调节肠道运动的“刹车”系统，能够动态影响消化道的推进速度。此外，针对人类基因组的研究进一步证实了该通路与便秘等肠道功能障碍存在临床相关性。这为开发针对性治疗肠道动力疾病的新药提供了重要的理论依据。References: Muppirala A N, Mitchell P E, Courtney E, et al. Tachykinin signaling defines distinct populations of glia in the enteric nervous system[J]. Neuron, 2026.前往小宇宙评论区与主播互动
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