EPISODE · Jan 31, 2026 · 17 MIN
453-II类嗅觉受体识别脂肪酸气味的机制研究
from 聊聊Sci
这项研究通过冷冻电镜技术揭示了II类嗅觉受体 Olfr110 识别疏水性气味分子的分子机制。研究人员发现该受体拥有一个比I类受体大得多的配体结合口袋，能够容纳如 PL45 和 12(S)-HEPE 等长链不饱和脂肪酸代谢物。通过结构分析和生化实验，论文阐明了受体如何利用特定的极性网络和芳香族残基簇来精准识别分子的官能团与双键。此外，研究还揭示了一种不同于经典GPCR的非常规激活路径，为开发针对受体的治疗药物提供了理论基础。该成果不仅拓展了人类对陆生生物嗅觉感知的理解，也指出了嗅觉受体在代谢调节等非嗅觉组织中的潜在药理价值。References: Han X, Zhang M H, Rong N K, et al. Mechanistic insights into fatty acid odor detection mediated by class II olfactory receptors[J]. Cell, 2026.前往小宇宙评论区与主播互动
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453-II类嗅觉受体识别脂肪酸气味的机制研究
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