EPISODE · Sep 22, 2025 · 49 MIN
46. Should Men Take Progesterone? How HRT Can Optimize Your Health
from The HRT University® Podcast · host Nico Misleh
Could a "female" hormone be the missing link to resolving anxiety, inflammation, and low energy in your male patients? What if the conventional wisdom that progesterone is useless for men is not only wrong, but dangerously outdated? In episode 46 of The Nico Misleh Podcast, host Nico Misleh dismantles the long-held myths surrounding progesterone in men's health. Discover the surprising new evidence showing its powerful anti-inflammatory effects, its role in improving mitochondrial function for more energy, and its neuroprotective qualities that could be vital for mental health and managing stress. This episode provides a vital clinical perspective on why and how to consider progesterone as part of a comprehensive hormone optimization strategy, moving beyond testosterone alone to achieve superior patient outcomes.Ready to confidently guide your patients through complex hormone protocols? Our HRT Master Course is the definitive training for clinicians who want to master hormone replacement therapy. Elevate your practice by enrolling today at https://hrtuniversity.com/hrtcourse/For practitioners who want to confidently grow their practice with guidance in TRT, HRT, and business strategy, find us below:- Nico's Daily Newsletter: https://nicomislenp.kit.com/8050eeea5f (yes, it's daily... and yes, people stay subscribed)- Join HRT University: https://hrtuniversity.com/- Join the HRT University Facebook Group: https://www.facebook.com/groups/1179376819949373/?ref=share&_rdrPlease summarize my stats over the last 7 days (views, watch time hours, click through rates and subscribers) and then please give me a comparison to the previous 7 days. Please make it positive and tell me where we are seeing success.Chapters:0:00 - Should Men Take Progesterone? A Clinician's Definitive Answer 1:24 - What Hormone TRULY Separates Men and Women? (It's Not Estrogen) 3:11 - Why Most Doctors Are WRONG About Progesterone in Men 4:13 - The "Junk Hormone" Myth: Why Your Body Doesn't Waste Resources 5:19 - What Is DHT and Why Is It Vital for BOTH Sexes? 6:49 - How A Progesterone "Side Effect" Cures Anxiety & Insomnia 8:04 - Are You Progesterone Resistant? A New Health Epidemic 9:34 - Does Progesterone Cause Inflammation in Men? A Look at the Conflicting Science 12:30 - How Progesterone Fights Deadly Inflammation (The COVID-19 ICU Study) 16:15 - A Surprising Link: How Progesterone Levels Correlate with Suicide Risk in Veterans 19:49 - The Connection Between Traumatic Brain Injury (TBI) and Low Hormones 22:07 - Gas vs. Brake Pedal: How Hormones Control Your Nervous System 23:04 - Meet the "Mother of All Hormones" and Her Calming Family 25:34 - Is Your Brain on Fire? The Glutamate vs. GABA Battle for Your Mood 26:56 - How a Patented Drug Mimics Progesterone to Treat PMDD & Postpartum 29:22 - Can Men Get the Same Calming Brain Benefits from Progesterone as Women? 30:52 - How Progesterone Acts as Your Body's Master Stress Regulator 32:17 - The Ultimate Health Principle: Why Energy is the Currency of Life 35:24 - How Aging Is a Disease of Energy Loss at the Cellular Level 37:26 - When Should a Clinician Prescribe Progesterone for a Male Patient? 38:45 - What Makes Men, Men? The Critical Role of Dihydrotestosterone (DHT) 40:06 - How to Treat Anxiety in Men: Testosterone First, Then Progesterone 41:19 - Can Progesterone Help with BPH and Prostate Health? 42:33 - How TRT Can Shut Down Your Body's Natural Hormone Production 45:14 - Are Human Beings a "Complicated" or "Complex" System? 47:22 - The #1 Rule of Hormone Therapy: 1+1 Does Not Always Equal 2 48:18 - How to Join the HRT University Community & Nico's Daily Newsletter
What this episode covers
Could a "female" hormone be the missing link to resolving anxiety, inflammation, and low energy in your male patients? What if the conventional wisdom that progesterone is useless for men is not only wrong, but dangerously outdated? In episode 46 of The Nico Misleh Podcast, host Nico Misleh dismantles the long-held myths surrounding progesterone in men's health. Discover the surprising new evidence showing its powerful anti-inflammatory effects, its role in improving mitochondrial function for more energy, and its neuroprotective qualities that could be vital for mental health and managing stress. This episode provides a vital clinical perspective on why and how to consider progesterone as part of a comprehensive hormone optimization strategy, moving beyond testosterone alone to achieve superior patient outcomes.Ready to confidently guide your patients through complex hormone protocols? Our HRT Master Course is the definitive training for clinicians who want to master hormone replacement therapy. Elevate your practice by enrolling today at https://hrtuniversity.com/hrtcourse/For practitioners who want to confidently grow their practice with guidance in TRT, HRT, and business strategy, find us below:- Nico's Daily Newsletter: https://nicomislenp.kit.com/8050eeea5f (yes, it's daily... and yes, people stay subscribed)- Join HRT University: https://hrtuniversity.com/- Join the HRT University Facebook Group: https://www.facebook.com/groups/1179376819949373/?ref=share&_rdrPlease summarize my stats over the last 7 days (views, watch time hours, click through rates and subscribers) and then please give me a comparison to the previous 7 days. Please make it positive and tell me where we are seeing success.Chapters:0:00 - Should Men Take Progesterone? A Clinician's Definitive Answer 1:24 - What Hormone TRULY Separates Men and Women? (It's Not Estrogen) 3:11 - Why Most Doctors Are WRONG About Progesterone in Men 4:13 - The "Junk Hormone" Myth: Why Your Body Doesn't Waste Resources 5:19 - What Is DHT and Why Is It Vital for BOTH Sexes? 6:49 - How A Progesterone "Side Effect" Cures Anxiety & Insomnia 8:04 - Are You Progesterone Resistant? A New Health Epidemic 9:34 - Does Progesterone Cause Inflammation in Men? A Look at the Conflicting Science 12:30 - How Progesterone Fights Deadly Inflammation (The COVID-19 ICU Study) 16:15 - A Surprising Link: How Progesterone Levels Correlate with Suicide Risk in Veterans 19:49 - The Connection Between Traumatic Brain Injury (TBI) and Low Hormones 22:07 - Gas vs. Brake Pedal: How Hormones Control Your Nervous System 23:04 - Meet the "Mother of All Hormones" and Her Calming Family 25:34 - Is Your Brain on Fire? The Glutamate vs. GABA Battle for Your Mood 26:56 - How a Patented Drug Mimics Progesterone to Treat PMDD & Postpartum 29:22 - Can Men Get the Same Calming Brain Benefits from Progesterone as Women? 30:52 - How Progesterone Acts as Your Body's Master Stress Regulator 32:17 - The Ultimate Health Principle: Why Energy is the Currency of Life 35:24 - How Aging Is a Disease of Energy Loss at the Cellular Level 37:26 - When Should a Clinician Prescribe Progesterone for a Male Patient? 38:45 - What Makes Men, Men? The Critical Role of Dihydrotestosterone (DHT) 40:06 - How to Treat Anxiety in Men: Testosterone First, Then Progesterone 41:19 - Can Progesterone Help with BPH and Prostate Health? 42:33 - How TRT Can Shut Down Your Body's Natural Hormone Production 45:14 - Are Human Beings a "Complicated" or "Complex" System? 47:22 - The #1 Rule of Hormone Therapy: 1+1 Does Not Always Equal 2 48:18 - How to Join the HRT University Community & Nico's Daily Newsletter
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46. Should Men Take Progesterone? How HRT Can Optimize Your Health
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