46,XY DSD: Find Where the Biological Signal Failed | S5E3

A 46,XY karyotype tells you the chromosomes. It does not tell you whether a functional testis formed, whether Sertoli and Leydig signaling occurred normally, whether testosterone was converted to DHT, or whether androgen action was intact.This episode builds a mechanistic framework for evaluating 46,XY DSD by tracing the biological signal from gonadal determination to phenotype.The practical goal is simple: stop memorizing syndromes and identify where the biological signal failed.