EPISODE · Feb 1, 2026 · 19 MIN
460-颅骨免疫细胞：跨越血脑屏障的卒中给药新策略
from 聊聊Sci
这项研究介绍了一种名为经颅骨内注射（ICO）的创新给药策略，旨在通过“劫持”头盖骨中的免疫细胞来绕过血脑屏障（BBB），从而治疗中枢神经系统疾病。研究人员利用负载药物的白蛋白纳米颗粒与头盖骨骨髓中的髓系细胞结合，这些细胞能对脑部病变做出反应，并经由连接颅骨与脑膜的微通道将药物精准递送至受损区域。在小鼠模型实验中，该方法显著提升了缺血性中风的治疗效果，不仅缩小了梗死面积，还改善了长期的认知和运动功能。此外，初步的临床试验验证了ICO技术在人体应用中的可行性与安全性，为神经系统疾病的靶向治疗提供了极具潜力的新型平台。References: Gao X, Liu X, Wang N, et al. Nanoparticles hijack calvarial immune cells for CNS drug delivery and stroke therapy[J]. Cell, 2026.前往小宇宙评论区与主播互动
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460-颅骨免疫细胞：跨越血脑屏障的卒中给药新策略
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