EPISODE · Feb 1, 2026 · 18 MIN
463-三阴性乳腺癌免疫治疗响应的空间预测因子
from 聊聊Sci
这项研究利用成像质谱流式技术（IMC），深入分析了三阴性乳性癌（TNBC）患者在接受免疫治疗前后的肿瘤微环境。科研人员通过追踪43种蛋白质标记物的分布，揭示了细胞间的空间组织结构如何决定药物的有效性。研究发现，治疗前CD8+TCF1+T细胞的增殖比例是预测疗效的关键指标。而在治疗过程中，CD8+GZMB+T细胞的聚集预示着积极的临床反应，相反，CD15+癌细胞的增加则通常伴随着耐药性。这些发现强调了空间生物学特征在精准免疫治疗中的重要价值。这项成果不仅有助于筛选治疗获益人群，也为理解肿瘤如何重塑自身结构以对抗治疗提供了新见解。References: Wang, X.Q., Danenberg, E., Huang, CS. et al. Spatial predictors of immunotherapy response in triple-negative breast cancer. Nature 621, 868–876 (2023). doi.org前往小宇宙评论区与主播互动
Embed this episode
Ready to play
463-三阴性乳腺癌免疫治疗响应的空间预测因子
0:00
18:15
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 18 minutes long.
When was this 聊聊Sci episode published?
This episode was published on February 1, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!