EPISODE · Feb 5, 2026 · 23 MIN
477-人类代谢功能障碍相关脂肪肝空间多组学图谱
from 聊聊Sci
这项研究通过单细胞转录组学和空间多组学技术，深入分析了代谢功能相关脂肪性肝病（MASLD）的病理机制。研究人员发现一种名为脂质相关巨噬细胞（LAMs）的特定免疫细胞在疾病恶化过程中显著增加，并确认MITF转录因子是调控其脂质处理能力和线粒体功能的关键。通过空间定位分析，研究揭示了这些巨噬细胞主要分布在肝小叶的近中央静脉区域，并通过HGF-MET信号轴发挥保护肝细胞、抑制凋亡的作用。此外，该研究还识别了与肝脏纤维化相关的RSPO3-LGR6等细胞间交互通路。这些发现为MASLD的精准诊断和新型药物靶点开发提供了详尽的分子图谱。References: Li Z, Luo G, Gan C, et al. Spatially resolved multi-omics of human metabolic dysfunction-associated steatotic liver disease[J]. Nature Genetics, 2025: 1-14.前往小宇宙评论区与主播互动
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