EPISODE · Feb 6, 2026 · 18 MIN
481-肠道共生菌通过跨分化增强肿瘤免疫治疗效应
from 聊聊Sci
这项研究探讨了肠道微生物群如何通过抗原模拟机制增强癌症免疫治疗的效果。研究发现，在分节丝状菌（SFB）存在的情况下，肠道内被诱导产生的TH17细胞能够迁移至远端肿瘤部位。这些细胞在进入肿瘤后会转化成具有促炎特性的TH1-like细胞，并招募CD8+杀伤性T细胞，从而显著提升PD-1抑制剂的抗肿瘤疗效。与之相反，虽然肝螺旋杆菌（Hh）也能诱导T细胞迁移，但由于其维持了抑制性的调节表型，因此无法增强免疫治疗。这一发现证明了特定肠道细菌可以通过提供与肿瘤相似的抗原，来重塑肿瘤微环境并改善临床预后。因此，该研究为利用特定的共生菌来优化癌症免疫疗法提供了重要的理论依据和实践路径。References: Najar T A, Hao Y, Hao Y, et al. Microbiota-induced T cell plasticity enables immune-mediated tumour control[J]. Nature, 2026: 1-10.前往小宇宙评论区与主播互动
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481-肠道共生菌通过跨分化增强肿瘤免疫治疗效应
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