EPISODE · Feb 7, 2026 · 19 MIN
484-支链氨基酸代谢重启造血干细胞再生潜能
from 聊聊Sci
这项研究揭示了造血干细胞（HSCs）的功能衰减与细胞分裂历史及代谢重构之间的深层联系。研究发现，随着细胞分裂次数的增加，造血干细胞会发生转录和功能漂移，导致其分化出的血液系统在谱系比例和基因表达上出现不稳定性。这种退化源于支链氨基酸（BCAA）代谢模式的转变，即从原有的分解代谢转向合成代谢，从而加速了细胞周期。通过补充BCAA代谢产物$\alpha$-酮异己酸（aKIC），可以重新激活代谢流并减缓细胞分裂速度，从而修复受损干细胞的再生能力。这一发现挑战了干细胞自我更新无限性的传统认知，并为再生医学提供了通过代谢干预恢复干细胞活力的潜在手段。References: Bartram J, Treichel S, Song B A, et al. Activation of a branched-chain amino acid rheostat restores replication-dependent hematopoietic stem cell fitness[J]. Cell Stem Cell, 2026.前往小宇宙评论区与主播互动
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484-支链氨基酸代谢重启造血干细胞再生潜能
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