EPISODE · Feb 9, 2026 · 16 MIN
488-类泛素化调控神经元衰老与阿兹海默症病变
from 聊聊Sci
这项研究利用全基因组 CRISPR 筛选技术，在人类多能干细胞模型中探索神经元衰老与阿尔茨海默病（AD）及帕金森病（PD）等迟发性疾病之间的联系。研究人员发现类泛素化（Neddylation）通路是调节神经元年龄的关键因子，通过抑制该通路可以诱发细胞的衰老特征。实验证明，衰老信号与遗传风险具有协同作用，能够触发β-淀粉样蛋白积聚、Tau蛋白病理改变及神经元死亡。该发现不仅揭示了迟发性神经退行性疾病的潜在治疗靶点，还为在体外模型中模拟老年性表型提供了新的策略。研究强调，通过药物诱导衰老可以更精准地捕获此前在年轻神经元模型中难以观察到的疾病特征。References: Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration Saurat, Nathalie et al.Cell Stem Cell, Volume 31, Issue 8, 1162 - 1174.e9前往小宇宙评论区与主播互动
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488-类泛素化调控神经元衰老与阿兹海默症病变
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