EPISODE · Feb 11, 2026 · 16 MIN
496-血管化视网膜类器官的神经生存与功能发育
from 聊聊Sci
这项研究介绍了一种生物工程平台，通过整合人诱导多能干细胞衍生的内皮细胞，构建具有血管网络的功能性类人视网膜模型。研究人员开发了名为AMASS的改良方案，有效解决了传统视网膜类器官因缺乏血管导致内部缺氧及视网膜神经节细胞退化的难题。实验结果表明，血管化类器官不仅体积更大且细胞存活率更高，还能展现出更强的电生理活性和对不同波长光线的功能性反应。这一创新模型模拟了人类视网膜的复杂层级结构，为视网膜疾病的病理研究和药物开发提供了高度仿生的体外工具。References: Sharma K, Habibey R, Ribeiro M M, et al. Retinal ganglion cell survival and functional maturation in transiently vascularized human retinal organoids[J]. Cell Stem Cell, 2026.前往小宇宙评论区与主播互动
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496-血管化视网膜类器官的神经生存与功能发育
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