49ers' ultimate goal in focus with regular-season finale on horizon

With a number of limited or nonparticipants in the 49ers' first practice of the week, depth players once again will need to step up and fill their role. What's also familiar is San Francisco's opponent in the regular-season finale on Saturday at Levi's Stadium: Sam Darnold and the Seattle Seahawks. On this episode of "49ers Talk," co-hosts Matt Maiocco and Jennifer Lee Chan discuss how clutch San Francisco's depth has been this season, especially in prime-time games. Also, they detail the many playoff permutations that will swirl following Week 18's results, along with just how much defensive coordinator Robert Saleh trusts his players and if Deommodore Lenoir will get a chance to shadow one of the league's best receivers Saturday in Jaxon Smith-Njigba.--(2:00) 49ers face familiar foe in regular-season finale(4:00) Why 49ers' clutch gene in prime-time games plays to their advantage(8:00) Injury updates, which backups have been impressive this season(12:00) Playoff implications based on Week 18 results(18:00) Discussing Robert Saleh's trust in defense(21:00) Will Lenoir be asked to shadow JSN? Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.