5 1 2025

Hi, This Week in Medicine, we will be discussing First we will be discussing articles in New England Journal of MedicineLepodisiran — A Long-Duration Small Interfering RNA Targeting Lipoprotein(a) Identification of Hepatic-like EPO as a Cause of Polycythemia Lentiviral Gene Therapy for Severe Leukocyte Adhesion Deficiency Type 1 Mepolizumab to Prevent Exacerbations of COPD with an Eosinophilic Phenotype Journal of  American Medical AssociationMidurethral Sling vs OnabotulinumtoxinA in Females With Urinary IncontinenceThe MUSA Randomized Clinical Trial  Annals of Internal MedicineSexual Trauma, Suicide, and Overdose in a National Cohort of Older Veterans British Medical JournalUse of gabapentinoid treatment and the risk of self-harm  LancetOral gepotidacin for the treatment of uncomplicated urogenital gonorrhoea (EAGLE-1): a phase 3 randomised, open-label, non-inferiority, multicentre study Journal of Clinical OncologySupervised Exercise for Patients With Metastatic Breast Cancer  journal of HepatologyMetabolic dysfunction-associated steatohepatitis reduces interferon and macrophage liver gene signatures in patients with chronic hepatitis B Gastroenterology Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood Journal of Clinical Rheumatology Salivary β2-Microglobulin, Na+, and Cortisol Levels, and Salivary Glands' Uptakes in Sialoscintigraphy in Sjögren Disease  CirculationNrf3-Mediated Mitochondrial Superoxide Promotes Cardiomyocyte Apoptosis and Impairs Cardiac Functions by Suppressing Pitx2 Journals of the American College of CardiologyNonlinear Relation Between Cardiac Mortality and Excess Temperature in Heatwaves: Exposure Response in 2.39 Million Patients From JAMA CardiologySalt Substitution and Recurrent Stroke and DeathA Randomized Clinical Trial  Journal of Clinical Endocrinology & MetabolismDigital Voice Analysis as a Biomarker of Acromegaly   ChestTreatment of Acute Circulatory Failure Based on Carbon Dioxide-Oxygen (CO2-O2) Derived IndicesThe Lactel Randomized Multicenter Study  Next we will be discussing articles In the field of Nephrology Here are the  articles   from Kidney International reportsImproving Blood Pressure in High-Risk Patients With CKD Using an Interdisciplinary Remote Hypertension Program Outcomes for Patients With a Deceased Donor Kidney Offer in the New Allocation System