5 1 2025

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Lepodisiran — A Long-Duration Small Interfering RNA Targeting Lipoprotein(a)

Identification of Hepatic-like EPO as a Cause of Polycythemia

Lentiviral Gene Therapy for Severe Leukocyte Adhesion Deficiency Type 1

Mepolizumab to Prevent Exacerbations of COPD with an Eosinophilic Phenotype

 Journal of  American Medical Association

Midurethral Sling vs OnabotulinumtoxinA in Females With Urinary Incontinence

The MUSA Randomized Clinical Trial

  Annals of Internal Medicine

Sexual Trauma, Suicide, and Overdose in a National Cohort of Older Veterans

 British Medical Journal

Use of gabapentinoid treatment and the risk of self-harm

  Lancet

Oral gepotidacin for the treatment of uncomplicated urogenital gonorrhoea (EAGLE-1): a phase 3 randomised, open-label, non-inferiority, multicentre study

 Journal of Clinical Oncology

Supervised Exercise for Patients With Metastatic Breast Cancer

  journal of Hepatology

Metabolic dysfunction-associated steatohepatitis reduces interferon and macrophage liver gene signatures in patients with chronic hepatitis B

 Gastroenterology

Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood

 Journal of Clinical Rheumatology 

Salivary β2-Microglobulin, Na+, and Cortisol Levels, and Salivary Glands' Uptakes in Sialoscintigraphy in Sjögren Disease

  Circulation

Nrf3-Mediated Mitochondrial Superoxide Promotes Cardiomyocyte Apoptosis and Impairs Cardiac Functions by Suppressing Pitx2

 Journals of the American College of Cardiology

Nonlinear Relation Between Cardiac Mortality and Excess Temperature in Heatwaves: Exposure Response in 2.39 Million Patients

From JAMA Cardiology

Salt Substitution and Recurrent Stroke and DeathA Randomized Clinical Trial

  Journal of Clinical Endocrinology & Metabolism

Digital Voice Analysis as a Biomarker of Acromegaly 

  Chest

Treatment of Acute Circulatory Failure Based on Carbon Dioxide-Oxygen (CO2-O2) Derived Indices

The Lactel Randomized Multicenter Study

Next we will be discussing articles In the field of Nephrology

Here are the  articles   from Kidney International reports

Improving Blood Pressure in High-Risk Patients With CKD Using an Interdisciplinary Remote Hypertension Program

Outcomes for Patients With a Deceased Donor Kidney Offer in the New Allocation System