5 13 2-24

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Exagamglogene Autotemcel for Severe Sickle Cell Disease

Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia

Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size

 Journal of  American Medical Association

Ponatinib vs Imatinib in Frontline Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia

Associations of Internal Medicine Residency Milestone Ratings and Certification Examination Scores With Patient Outcomes

Annals of Internal Medicine

The Safety of Outpatient Health Care: Review of Electronic Health Records

Diagnostic Strategy Using Color Doppler Ultrasound of Temporal Arteries in Patients With High Clinical Suspicion of Giant Cell Arteritis: A Prospective Cohort Study

Nature Medicine

Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis

Lancet

Preventive percutaneous coronary intervention versus optimal medical therapy alone for the treatment of vulnerable atherosclerotic coronary plaques (PREVENT): a multicentre, open-label, randomised controlled trial

Journal of Clinical Oncology

Phase II Trial of nab-Sirolimus in Patients With Advanced Malignant Perivascular Epithelioid Cell Tumors (AMPECT): Long-Term Efficacy and Safety Update

 journal of Hepatology

Clinical profiles and mortality rates are similar for metabolic dysfunction-associated steatotic liver disease and non-alcoholic fatty liver disease

Molecular force-induced liberation of transforming growth factor-beta remodels the spleen for ectopic liver regeneration

Clinical Gastroenterology

Type 1 Autoimmune Pancreatitis in Europe: Clinical Profile and Response to Treatment

Screening for Fibrosis Promotes Lifestyle Changes: A Prospective Cohort Study in 4796 Individuals

ENTERPRET: A Randomized Controlled Trial of Vedolizumab Dose Optimization in Patients With Ulcerative Colitis Who Have Early Nonresponse

  Clinical Infectious Diseases

Impact of a Purified Microbiome Therapeutic on Abundance of Antimicrobial Resistance Genes in Patients With Recurrent Clostridioides difficile Infection

A Systematic Review of Predictor Composition, Outcomes, Risk of Bias, and Validation of COVID-19 Prognostic Scores

Compared Performance of the 2023 Duke–International Society for Cardiovascular Infectious Diseases, 2000 Modified Duke, and 2015 European Society of Cardiology Criteria for the Diagnosis of Infective Endocarditis in a French Multicenter Prospective Cohort

 Journal of Clinical Rheumatology 

Measurement of Neutrophil Extracellular Traps as a Biomarker for the Differential Diagnosis Between Antineutrophil Cytoplasmic Antibody–Positive Individuals With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis and Nonautoimmune Diseases

Prediction of Treatment Effect of SLE-ITP Patients Based on Cost-Sensitive Neural Network and Variational Autoencoder

  Arthritis and Rheumatology

Anti-Inflammatory Effect of High-Density Lipoprotein Blunted by Delivery of Altered MicroRNA Cargo in Patients With Rheumatoid Arthritis

American College of Cardiology

LGE CMR and Sudden Death in Hypertrophic Cardiomyopathy 

 Journals of the American College of Cardiology

Sacubitril/Valsartan-Related Hypotension in Patients With Heart Failure and Preserved or Mildly Reduced Ejection Fraction

 Journal of Clinical Endocrinology & Metabolism

Association Between a History of Breast Cancer and Decreased Thyroid Cancer-specific Mortality

Neurology:

Association of Coffee Consumption and Prediagnostic Caffeine Metabolites With Incident Parkinson Disease in a Population-Based Cohort

Chest

Symptoms and Impaired Quality of Life After COVID-19 Hospitalization: Effect of Therapeutic Heparin in Non-ICU Patients in the Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 Acute Trial

Use and Outcomes of Peripheral Vasopressors in Early Sepsis-Induced Hypotension Across Michigan Hospitals

  The American Journal of Respiratory and Critical Care Medicine

Zinpentraxin Alfa for Idiopathic Pulmonary Fibrosis: The Randomized Phase III STARSCAPE Trial

  Clinical Journal of American Society of Nephrology

Associations of Angiopoietin 2 and Vascular Endothelial Growth Factor-A Concentrations with Clinical End Points

The Association of Intra-Abdominal Adhesions with Peritoneal Dialysis Catheter-Related Complications

Kidney International reports

Early Rituximab as an Add-On Therapy in Children With the Initial Episode of Nephrotic Syndrome

Aversion to a High Salt Taste is Disturbed in Patients With CKD