5 26 2025

Hi, This Week in Medicine, we will be discussingNew England Journal of MedicineOveporexton, an Oral Orexin Receptor 2–Selective Agonist, in Narcolepsy Type 1 Second-Line Antiretroviral Therapy for Children Living with HIV in Africa Journal of  American Medical AssociationDexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial A Multidimensional Diagnostic Approach for Chronic Obstructive Pulmonary Disease Annals of Internal MedicineComparison of Dose Escalation Versus Switching to Tirzepatide Among People With Type 2 Diabetes Inadequately Controlled on Lower Doses of Dulaglutide British Medical JournalEffects of a general practitioner-led brief narrative exposure intervention on symptoms of post-traumatic stress disorder after intensive care (PICTURE): multicentre, observer blind, randomised controlled trial LancetEfficacy and safety of topical delgocitinib cream versus oral alitretinoin capsules in adults with severe chronic hand eczema (DELTA FORCE): a 24-week, randomised, head-to-head, phase 3 trial  Gastroenterology Mechanistic Implications of the Mediterranean Diet in Patients With Newly Diagnosed Crohn's Disease: Multiomic Results From a Prospective Cohort Clinical Gastroenterology The Lactulose Breath Test Can Predict Refractory Gastroesophageal Reflux Disease by Measuring Bacterial Overgrowth in the Small Intestine Rheumatology A Catalog of “Knee Friendly” Aerobic Exercises Developed for Patients With Knee Osteoarthritis: An International Patient Survey Journal of Clinical Rheumatology Association of Klotho and Gout in Middle-Aged and Older Adults: National Health and Nutrition Survey (2007–2016)  CirculationOutcomes of Transcatheter Aortic Valve Replacement in Low-Risk Patients in the United States: A Report From the STS/ACC TVT Registry Journals of the American College of CardiologyEffect of Empagliflozin on the Mechanisms Driving Erythropoiesis and Iron Mobilization in Patients With Heart Failure: The EMPEROR Program JAMA CardiologyLong-Term Aspirin vs Clopidogrel After Coronary Stenting by Bleeding Risk and Procedural Complexity  Journal of Clinical Endocrinology & MetabolismRisk of Type 2 Diabetes, MASLD and Cardiovascular Disease in People Living With Polycystic Ovary Syndrome Diabetes careEarly Fasting Serum Glucose or Weight Reduction With Tirzepatide and Metabolic Outcomes in People With Type 2 Diabetes: A Post Hoc Analysis of the SURPASS Trials NeurologyRisk of False Acetylcholine Receptor Autoantibody Positivity by Radioimmunoprecipitation Assay in Clinical Practice ChestLow-Dose Melatonin for Prevention of Delirium in Critically Ill Patients The American Journal of Respiratory and Critical Care MedicinePopulation-Based Screening for Chronic Obstructive Pulmonary Disease Using the St. George’s Respiratory Questionnaire in Resource-Limited Settings  Clinical Journal of American Society of NephrologyPredicting Kidney Outcomes in Autosomal Dominant Polycystic Kidney Disease: A Comprehensive Biomarker Analysis Kidney International reportsProspective Cohort Study in Alport Syndrome Patients Under Standard Therapy