5 Ways to Support Your Body During Perimenopause

Liver Boost from MSW Nutrition is designed to support phase 1 and phase 2 detoxification pathways — the exact processes your liver uses to metabolize and clear estrogen. During perimenopause, when hormone levels fluctuate and detox pathways can become sluggish, supporting liver function is foundational. Liver Boost helps your body process hormones more efficiently, which can ease bloating, mood swings, skin changes, and stubborn weight fluctuations discussed throughout this episode. 👉 Get Liver Boost here: https://mswnutrition.com/products/liver-boost Perimenopause can feel confusing and overwhelming as hormones shift, sleep gets disrupted, and weight starts behaving differently. In this episode, we break down 5 practical ways to support your body during perimenopause — from liver detoxification and gut repair to adrenal support, insulin management, and the lab work you should be asking for. Learn how estrogen metabolism actually works and what you can do today to feel better through the transition. JOIN THE SCHOOL If perimenopause has you feeling confused about what's happening with your hormones, your gut, your weight, or your energy — you don't have to figure it out alone. Inside the School of Doza, you'll join a community of people navigating the same hormonal shifts, with access to live classes that go deeper into metabolism, digestion, and real-world strategies you can apply immediately.  👉 Start your free trial: https://community.schoolofdoza.com/c/start-here 5 KEY TAKEAWAYS Your liver is the gatekeeper of estrogen balance. Estrogen is metabolized primarily in the liver through a two-stage detoxification process — hydroxylation followed by methylation and sulfation. If these pathways are sluggish, excess estrogen can recirculate and amplify perimenopause symptoms. Gut health directly impacts estrogen levels. The estrobolome — a collection of gut bacteria genes — produces enzymes that deconjugate estrogen in the intestine. When gut health is compromised, the balance between estrogen reabsorption and excretion gets disrupted, potentially contributing to estrogen-driven conditions including breast cancer risk. Your adrenal glands become a key estrogen source. As ovarian function declines during perimenopause, the adrenal glands and adipose tissue continue producing estrogen locally. Supporting adrenal health helps maintain more stable hormone output during the transition. Insulin and estrogen are deeply connected. Research suggests that estrogen helps regulate plasma glucose and insulin levels.  Lab work removes the guesswork. Testing E2, progesterone, LH, FSH, DHEA-s, total and free testosterone, along with liver and inflammation markers like GGT, hsCRP, fasting insulin, and homocysteine gives you a clear picture of where your body actually stands — not just where you think it is based on symptoms. TIMESTAMPS 00:00 START – Welcome and episode overview 02:15 – What perimenopause actually is and why it feels so unpredictable 05:30 – Way #1: Detox the liver and how estrogen metabolism works in two phases 09:45 – The link between menopause and non-alcoholic fatty liver disease (NAFLD) 13:00 – Xenoestrogens, BPA, DDT, and environmental hormone disruptors 17:20 – Phytoestrogens and pterostilbene as protective agents 20:00 – Phase 2 detoxification: sulfation, methylation, and COMT 24:10 – Way #2: Repair the gut and how the estrobolome regulates estrogen 28:30 – How gut microbial beta-glucuronidase connects to breast cancer risk 32:00 – Way #3: Support the adrenals as a secondary estrogen source 35:15 – Way #4: Lower insulin and the estrogen-glucose connection 38:40 – Way #5: Get your labs done — the complete panel you should request 42:00 – How Liver Boost supports perimenopause and closing thoughts RESOURCES "Menopause and Non-Alcoholic Fatty Liver Disease": https://pmc.ncbi.nlm.nih.gov/articles/PMC5763482/ "Estrogen Sulfotransferase and Steroid Sulfatase in Cancer"  https://pmc.ncbi.nlm.nih.gov/articles/PMC3586502/ "Gut Microbial Beta-Glucuronidase: A Vital Regulator in Female Estrogen Metabolism"  https://pmc.ncbi.nlm.nih.gov/articles/PMC10416750/ "Xenoestrogens and Phytoestrogens:  https://pubmed.ncbi.nlm.nih.gov/34445499/ "Pterostilbene: Anticancer Effects Through Autophagy Induction": https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1323377/full "Estrogen Circulation Pathways"  https://www.researchgate.net/figure/Estrogen-circulation-pathways-Estrogens-are-locally-produced-in-several-tissues-mainly_fig1_349967427 CONNECT 🔗 Connect with Nurse Doza: JOIN MY SCHOOL for FREE: https://community.schoolofdoza.com/c/start-here YouTube: https://www.youtube.com/channel/UCwcKyagDi468WscAOWM5VHA Instagram: https://www.instagram.com/nursedoza/ Website: http://www.nursedoza.com/ LinkedIn: https://www.linkedin.com/in/jonathan-mendoza-dc-aprn-np-c-0609a038/ TikTok: https://www.tiktok.com/@nursedoza Twitter: https://twitter.com/nursedoza