EPISODE · Feb 14, 2026 · 20 MIN
505-双特异性多肽-纳米酶偶联物抗肿瘤研究
from 聊聊Sci
这项研究介绍了一种名为 BsPNEC 的双特异性肽-纳米酶结合物，旨在克服癌症免疫治疗中的耐药性。研究人员首先通过结构优化设计出一种能同时阻断 PD-L1（恢复 T 细胞功能）和 CXCR1/2（减少免疫抑制细胞浸润）的双功能多肽 qGA。随后将其与 Fe3O4 纳米酶 结合，利用纳米酶产生的活性氧激活 cGAS-STING 通路，从而进一步增强 T 细胞对肿瘤的攻击。实验证明，该平台在耐药性胰腺癌等模型中展现了显著的治疗效果，并集成了 磁共振成像（MRI） 示踪功能。这种多模态策略通过重塑肿瘤微环境，为协同增强癌症免疫疗法提供了新途径。References: Chen D, Xu R, Ye X, et al. Design of a bispecific peptide-nanozyme conjugate for cancer immunotherapy[J]. Cell Reports Medicine, 2026.前往小宇宙评论区与主播互动
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505-双特异性多肽-纳米酶偶联物抗肿瘤研究
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