EPISODE · Feb 16, 2026 · 19 MIN
510-食管癌演进的单细胞空间多阶段演化图谱
from 聊聊Sci
这项研究利用空间转录组学技术（如 Xenium 和 TF-seqFISH）深入分析了食管鳞状细胞癌（ESCC）从癌前病变到恶性肿瘤的演变过程。研究人员发现了四种具有独特分子特征的上皮细胞亚群，并揭示了由 JAG1-NOTCH1 信号通路驱动的“CAF-Epi 生态位”形成机制。这种特定的细胞相互作用不仅诱导了细胞外基质重塑，还通过招募抑制性免疫细胞建立了免疫逃逸屏障。基于这些发现，研究团队构建了一个整合了上皮侵袭性、成纤维细胞及免疫状态的 CAF-Epi-Immune 评分系统。该评分在多种鳞状细胞癌中展现出卓越的预后预测能力，为早期干预和临床诊断提供了关键的分子指标。References: Chang J, Lu J, Liu Q, et al. Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis[J]. Cancer Cell, 2025, 43(3): 380-397. e7.前往小宇宙评论区与主播互动
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510-食管癌演进的单细胞空间多阶段演化图谱
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