518-Gaia：感知基因组上下文的蛋白质序列注释平台

这项研究介绍了一个名为 Gaia 的新型 AI 驱动平台，专门用于蛋白质序列的功能注释和相似性搜索。与传统工具不同，Gaia 利用基因组语言模型 gLM2，不仅分析蛋白质本身的序列，还整合了其所在的基因组上下文环境。这种创新的方法能够识别出传统手段容易忽略的远源同源物，并显著提升了在微生物系统中的搜索精度。Gaia 支持对包含超过 8500 万个蛋白质簇的庞大数据库进行实时搜索，且其运算速度比现有的结构对齐方法快出数个数量级。通过分析基因邻里关系，该工具为揭示假定蛋白质的功能以及发现新型生物合成基因簇提供了强大的支持。目前，研究团队已将该平台作为免费在线工具向全球科研人员开放。References: Jha N, Kravitz J, West-Roberts J, et al. Gaia: An AI-enabled genomic context–aware platform for protein sequence annotation[J]. Science Advances, 2025, 11(25): eadv5109.前往小宇宙评论区与主播互动

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518-Gaia：感知基因组上下文的蛋白质序列注释平台

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