530-空间转录组学技术与分析方法全景综述

这篇来自《Science Bulletin》的综述文章全面探讨了空间转录组学（ST）的最新进展，重点介绍了从实验平台到计算工具及数据库的完整生态系统。作者系统评估了包括成像技术（如ISH、ISS）和测序技术（如阵列式、ROI式）在内的77种技术，分析了它们在空间分辨率和检测效率上的优劣。为了应对海量多模态数据的处理挑战，研究团队开发了SpatialToolDB数据库，收录并分类了约600种用于数据预处理、去噪、细胞注释及细胞间通讯分析的计算工具。文章强调了空间背景在理解复杂生物网络和组织架构中的核心作用，特别是在肿瘤微环境研究中的应用。最后，作者指出了该领域在标准化、3D重建和多组学集成方面面临的瓶颈，并对AI驱动的自动化分析和临床转化前景进行了展望。References: Zi-Zhen Guo, Renyan Wu, Weixiang Li, Keyu Yang, Xuexiang Ying, Hamid Alinejad-Rokny, Youqiong Ye. Mapping biology in space: from spatial transcriptomics platforms to analytical tools and databases. Science Bulletin. 2026.前往小宇宙评论区与主播互动

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530-空间转录组学技术与分析方法全景综述

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