EPISODE · Feb 21, 2026 · 21 MIN
532-膀胱癌尿液液态活检的场效应校正监测
from 聊聊Sci
这项研究开发了一种名为 RePhyNERX 的新型液体活检技术，旨在提高膀胱癌患者尿液检测的准确性。研究人员发现，随着年龄增长，健康人尿液中也会出现类似癌症的基因突变，这种“场效应”往往会导致传统检测出现假阳性。通过对比肿瘤、正常组织及术后尿液，该方法能有效过滤非癌症干扰信号，精准识别微小残留病灶。在临床验证中，该技术成功将患者划分为手术反应者、BCG 免疫治疗反应者和无反应者三类。研究进一步揭示，肿瘤突变负荷（TMB）和预存的免疫炎症特征是预测 BCG 疗效的关键指标。这一成果为膀胱癌的个性化治疗和精准监测提供了重要的科学依据。References: Shi W Y, Liu K J, Esfahani M S, et al. Field-effect-informed urine liquid biopsy for bladder cancer[J]. Cell, 2026.前往小宇宙评论区与主播互动
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532-膀胱癌尿液液态活检的场效应校正监测
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