EPISODE · Sep 3, 2026 · 20 MIN
534-肠道干细胞自更新计数与分化开关
from 聊聊Sci
这项研究揭示了果蝇肠道干细胞通过一种内在的表观遗传计数机制，精确调控不同子代细胞产出比例的生物学过程。研究发现，这些干细胞在经历一次产生内分泌母亲细胞的非对称分裂后，会连续进行八次自稳态分裂来生成吸收性细胞，并在第九次分裂时准时切换回内分泌细胞的生产。这种计数功能由两种功能拮抗的组蛋白修饰（TrxG与PcG）共同驱动，其中活性标记随分裂逐次递减，而抑制标记则不断积累直至达到触发命运转换的阈值。该计数器具有极强的鲁棒性，即便在急性损伤诱导的加速分裂中依然能维持恒定的产出比例，确保肠道组织的稳态。这一发现不仅明确了干细胞发育保真度的分子基础，也为组织工程和分化障碍疾病的治疗提供了新的理论支撑。References:Tong D, Li A, Jiang Q, et al. Intestinal stem cells count self-renewal divisions to switch multipotency[J]. Nature, 2026: 1-10.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
534-肠道干细胞自更新计数与分化开关
0:00
20:56
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 20 minutes long.
When was this 聊聊Sci episode published?
This episode was published on September 3, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!