EPISODE · Feb 21, 2026 · 20 MIN
534-USIC多肽介导植物系统性气孔免疫机制
from 聊聊Sci
这项研究揭示了十字花科植物中一种名为系统性气孔免疫（SSIM）的快速防御机制。当叶片遭受病原菌侵染时，受感染部位会产生一种由uORF编码的小肽——系统性气孔免疫导体（USIC）。USIC通过韧皮部进行远距离运输，并由未受感染叶片中的SIRK1-KIN7受体复合物感知。这种感知诱导了MC4蛋白酶对KIN7的切割及亚细胞易位，进而激活AHA1质子泵和PIP2;1水通道蛋白。最终，这一信号通路协同作用促使全株气孔关闭，从而在物理层面阻断病原菌进入。这一机制不仅弥补了系统获得性抗性（SAR）启动缓慢的不足，还展示了植物如何利用非传统分泌通路和移动肽信号实现高效的全株免疫调节。References: Liu C, Yu Q, Jin Y, et al. An uORF-encoded mobile peptide sparks systemic stomatal immunity[J]. Cell, 2026.前往小宇宙评论区与主播互动
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