551-IGSF11-VISTA轴：弥漫性中线胶质瘤免疫治疗新靶点

这项研究探讨了弥漫性内源性脑桥胶质瘤（DMG）的肿瘤微环境及其免疫逃逸机制。通过单细胞测序与空间转录组学技术，研究人员在肿瘤中发现了三种具有独特免疫特征的空间微环境。其中，MES区域富含促炎信号和血源性免疫细胞，而占主导地位的AOO区域则表现出神经发育特征，并聚集了大量稳态小胶质细胞。研究重点锁定了IGSF11-VISTA这一免疫检查点轴，发现其在维持小胶质细胞的稳态、抑制免疫攻击中起关键作用。实验表明，通过基因敲除或抗体阻断干扰该轴，能有效重新激活大脑原位小胶质细胞对肿瘤的清除功能，从而显著延长实验模型的生存期。这为这种极具攻击性的儿童脑肿瘤提供了一种无需依赖系统性免疫招募的新型精准免疫治疗思路。References: Collot R, Ruiz-Moreno C, Honhoff C, et al. IGSF11-VISTA is a critical and targetable immune checkpoint axis in diffuse midline glioma[J]. Cancer Cell, 2026.前往小宇宙评论区与主播互动

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551-IGSF11-VISTA轴：弥漫性中线胶质瘤免疫治疗新靶点

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