552-靶向TREM2巨噬细胞的铠甲化CAR T疗法

这项研究开发了一种创新性的靶向巨噬细胞的CAR T细胞疗法，旨在克服实体瘤治疗中抗原异质性和免疫抑制环境的挑战。研究人员发现 TREM2 是多种实体瘤中抑制性肿瘤相关巨噬细胞（TAMs）的共有特征，并据此设计了能精准清除这些细胞的 hTREM2 CAR T 细胞。为了增强疗效，这些T细胞被装甲化，通过合成生物传感器在肿瘤微环境中局部释放 IL-12，从而重新编程免疫景观并激活 NK细胞。实验证明，该疗法能有效诱导肿瘤退缩，并通过精巧的基因电路设计避免了全身性的细胞毒性。这一策略通过靶向非肿瘤细胞成分，为实现广谱实体瘤的通用型细胞治疗提供了新路径。References:* Yagel G, Rimini D, von Locquenghien M, et al. Tumor-antigen-independent targeting of solid tumors by armored ...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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